AORTIC ENDOTHELIAL-CELL DAMAGE INDUCED BY BETA-VLDL AND MACROPHAGES INVITRO

被引：12

作者：

TANIMURA, N ^{[1
]}

ASADA, Y ^{[1
]}

HAYASHI, T ^{[1
]}

KISANUKI, A ^{[1
]}

SUMIYOSHI, A ^{[1
]}

机构：

[1] MIYAZAKI MED COLL,DEPT PATHOL 1,5200 KIHARA,MIYAZAKI 88916,JAPAN

来源：

ATHEROSCLEROSIS | 1990年 / 85卷 / 2-3期

关键词：

AORTIC ENDOTHELIAL CELL INJURY; BETA-VLDL; MONOCYTE MACROPHAGE; ANTIOXIDANTS;

D O I：

10.1016/0021-9150(90)90107-T

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We performed an in vitro study to assess damage to swine aortic endothelial cells by rabbit beta-VLDL and/or rabbit peritoneal macrophages. Incubation of cultured aortic endothelial cells with beta-VLDL, macrophages, or macrophage lysate induced endothelial cell damage time- and dose-dependently as estimated by [H-3]adenine release. Incubation of endothelial cells with both beta-VLDL and macrophages produced a synergistic effect on the increase of [H-3]adenine release. Pretreatment of the endothelial cells with some kinds of antioxidants (probucol 560-mu-g/ml, vitamin E 50-mu-M, superoxide dismutase-polyethylene glycol 0.5 mg/ml, or catalase-polyethylene glycol 0.5-1.0 mg/ml) significantly prevented the endothelial damage by beta-VLDL or macrophage lysate. We conclude that beta-VLDL and/or macrophages could induce endothelial cell damage and that some kinds of antioxidants could prevent it.

引用

页码：161 / 167

页数：7