CELL SHRINKAGE FOLLOWS, RATHER THAN MEDIATES, THE SHORT-TERM EFFECTS OF GLUCAGON ON CARBOHYDRATE-METABOLISM

被引：17

作者：

GAUSSIN, V

BAQUET, A

HUE, L

机构：

[1] Hormone and Metabolic Research Unit, Inst. Cellular/Molecular Pathology, University Louvain Medical School, B-1200 Brussels

来源：

BIOCHEMICAL JOURNAL | 1992年 / 287卷

关键词：

D O I：

10.1042/bj2870017

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The initial effects of glucagon on glycogen breakdown in isolated hepatocytes were found to be independent of cell volume and, when it occurred, cell shrinkage followed rather than mediated the glycogenolytic effect of glucagon. Similar conclusions could be drawn for the effect of glucagon on glycolysis/gluconeogenesis and for the antagonistic effect of insulin on glucagon action.

引用

页码：17 / 20

页数：4

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