PILOT-SCALE VERIFICATION OF BIOPROCESS MODELS

被引：7

作者：

CLARKSON, AI

BULMER, M

SIDDIQI, SF

TITCHENERHOOKER, NJ

机构：

[1] Advanced Centre for Biochemical Engineering, Department of Chemical and Biochemical Engineering, University College London, London, WC1E 7JE, Torrington Place

来源：

COMPUTERS & CHEMICAL ENGINEERING | 1994年 / 18卷

关键词：

MODEL VERIFICATION; PROCESS INTERACTIONS; PILOT-SCALE; INTRACELLULAR ENZYME RECOVERY;

D O I：

10.1016/0098-1354(94)80106-1

中图分类号：

TP39 [计算机的应用];

学科分类号：

081203 ; 0835 ;

摘要：

This paper describes how pilot-scale verification trials have improved the accuracy of process models used in the simulation of a process for the recovery and purification of an intracellular enzyme, alcohol dehydrogenase (ADH) from packed yeast. The trials have highlighted the unit operations where improvements in the models are required for improved accuracy. The effects of process perturbations are also used to examine the robustness of the predictive models.

引用

页码：S651 / S655

页数：5

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