METABOLIC ALTERATIONS IN THE NEONATE AND INFANT BRAIN DURING DEVELOPMENT - EVALUATION WITH PROTON MR SPECTROSCOPY

被引：72

作者：

KIMURA, H ^{[1
]}

FUJII, Y ^{[1
]}

ITOH, S ^{[1
]}

MATSUDA, T ^{[1
]}

IWASAKI, T ^{[1
]}

MAEDA, M ^{[1
]}

KONISHI, Y ^{[1
]}

ISHII, Y ^{[1
]}

机构：

[1] FUKUI MED SCH,DEPT PEDIAT,MATSUOKA,FUKUI 91011,JAPAN

来源：

RADIOLOGY | 1995年 / 194卷 / 02期

关键词：

BRAIN; GROWTH AND DEVELOPMENT; METABOLISM; INFANTS; NEWBORN; MAGNETIC RESONANCE (MR); SPECTROSCOPY;

D O I：

10.1148/radiology.194.2.7529934

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

PURPOSE: To evaluate the usefulness of hydrogen-1 magnetic resonance (MR) spectroscopy in the evaluation of the developing brain. MATERIALS AND METHODS: Localized MR spectra were obtained with an echo time of 272 msec from the brain of 78 neonates and infants aged 1 week to 100 months. All patients were retrospectively classified into three groups on the basis of neurologic development: abnormal (group 2, n = 21), normal despite minor neurologic signs (group 1, n = 23), and normal (group 0, n = 34). RESULTS: Seventeen patients in group 2 and eight patients in group 1 revealed abnormally low N-acetylaspartate (NAA)/choline or NAA/creatine ratios compared with those obtained in group 0. MR spectroscopy was slightly more useful in the differentiation of patients in groups 2 and 1 (x(2) test, P <.005) than MR imaging (P <.01). CONCLUSION: H-1 MR spectroscopy provides prognostic information about the brain in healthy and neurologically damaged infants and augments the value of MR imaging.

引用

页码：483 / 489

页数：7

共 27 条

[11] CEREBRAL LACTATE AND N-ACETYL-ASPARTATE/CHOLINE RATIOS IN ASPHYXIATED FULL-TERM NEONATES DEMONSTRATED IN-VIVO USING PROTON MAGNETIC-RESONANCE SPECTROSCOPY [J].