THE MALELESS PROTEIN ASSOCIATES WITH THE X-CHROMOSOME TO REGULATE DOSAGE COMPENSATION IN DROSOPHILA

被引:257
作者
KURODA, MI
KERNAN, MJ
KREBER, R
GANETZKY, B
BAKER, BS
机构
[1] STANFORD UNIV, DEPT BIOL SCI, STANFORD, CA 94305 USA
[2] UNIV WISCONSIN, GENET LAB, MADISON, WI 53706 USA
关键词
D O I
10.1016/0092-8674(91)90439-6
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The maleless (mle) gene is one of four known regulatory loci required for increased transcription (dosage compensation) of X-linked genes in D. melanogaster males. A predicted mle protein (MLE) contains seven short segments that define a superfamily of known and putative RNA and DNA helicases. MLE, while present in the nuclei of both male and female cells, differs in its association with polytene X chromosomes in the two sexes. MLE is associated with hundreds of discrete sites along the length of the X chromosome in males and not in females. The predominant localization of MLE to the X chromosome in males makes it a strong candidate to be a direct regulator of dosage compensation.
引用
收藏
页码:935 / 947
页数:13
相关论文
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