EFFECT OF CORTISONE ON CELLS AT THE BONE-MARROW INTERFACE

被引:11
作者
SIMMONS, DJ [1 ]
KIDDER, L [1 ]
THOMAS, M [1 ]
机构
[1] UNIV TEXAS, MED BRANCH, DEPT PHARMACOL & TOXICOL, GALVESTON, TX 77550 USA
关键词
Bone formation; Glucocorticoid; Marrow; Osteopenia; Stromal cell;
D O I
10.1007/BF02563824
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
A study of the association between the rate of proliferation of marrow fibroblast-like stromal cells (in vitro) and the rate of endosteal bone mineralization (EsMR) (in vivo) was undertaken in an osteopenic rat model. We report than 200 g male rats treated with cortisone acetate (5 mg/day for 7 days) exhibit decreases in marrow fibroblast colony-forming units (FCFU) and tetracycline-based measurements of EsMR at the level of the femoral midshaft. In cortisone-treated rats recovering for 1-3 weeks, the FCFU census and EsMR normalized during the first posttreatment week, remained at control levels after 2-3 weeks, and exhibited a relapse in the third week which signified only partial recovery. These changes were unrelated to patterns of body weight gain. The data indicate that the FCFU census can serve to index endosteal osteoblast vigor. © 1990 Springer-Verlag New York Inc.
引用
收藏
页码:327 / 332
页数:6
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