CALCIUM-INDEPENDENT PHOSPHODIESTERASE INHIBITORS AS PUTATIVE ANTIDEPRESSANTS - [3-(BICYCLOALKYLOXY)-4-METHOXYPHENYL]-2-IMIDAZOLIDINONES

被引：42

作者：

SACCOMANO, NA

VINICK, FJ

KOE, BK

NIELSEN, JA

WHALEN, WM

MELTZ, M

PHILLIPS, D

THADIEO, PF

JUNG, S

CHAPIN, DS

LEBEL, LA

RUSSO, LL

HELWEG, DA

JOHNSON, JL

IVES, JL

WILLIAMS, IH

机构：

[1] Central Research, Pfizer Inc., Groton

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1991年 / 34卷 / 01期

关键词：

D O I：

10.1021/jm00105a045

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The synthesis and biological properties of a novel series of selective calcium-independent phosphodiesterase inhibitors are described. These compounds also inhibit the specific binding of [H-3]rolipram to rat brain membranes and exhibit efficacy in preclinical models of antidepressant activity in mice, such as reducing immobility in the forced-swim test and reversing reserpine-induced hypothermia. Imidazolidinones 4 and 16 were found to be the most potent compounds studied.

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页码：291 / 298

页数：8

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