CATALYTIC ASYMMETRIC ALKYLATION OF ALDEHYDES BY DIETHYLZINC IN THE PRESENCE OF N-ISO-PROPYLEPHEDRINE - DEPENDENCE OF ENANTIOSELECTIVITY ON ET2ZN-RCHO

被引：51

作者：

CHALONER, PA

LANGADIANOU, E

机构：

[1] School of Chemistry and Molecular Sciences, University of Sussex, Falmer, Brighton

来源：

TETRAHEDRON LETTERS | 1990年 / 31卷 / 36期

关键词：

D O I：

10.1016/S0040-4039(00)97838-9

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The enantioselective alkylation of a range of aldehydes by diethylzinc in the presence of N-isopropylephedrine has been investigated. Both the yield and the enantioselectivity of the reaction was found to depend on the ratio of Et2Zn to the aldehyde. © 1990.

引用

页码：5185 / 5188

页数：4

共 14 条

[11] ASYMMETRIC-SYNTHESIS OF ALCOHOLS WITH 2 CHIRAL CENTERS FROM A RACEMIC ALDEHYDE BY THE SELECTIVE ADDITION OF DIALKYLZINC REAGENTS USING (1S,2R)-(-)-N,N-DIBUTYLNOREPHEDRINE AND (S)-(+)-DIPHENYL-(1-METHYLPYRROLIDIN-2-YL)METHANOL AS CHIRAL CATALYSTS
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SOAI, K
NIWA, S
WATANABE, M
[J]. JOURNAL OF ORGANIC CHEMISTRY, 1988, 53 (04) : 927 - 928
[13] CATALYTIC ENANTIOSELECTIVE CONJUGATE ADDITION OF DIALKYLZINCS TO ALPHA,BETA-UNSATURATED KETONES USING NICKEL BROMIDE-N, N-DIBUTYLNOREPHEDRINE
SOAI, K
HAYASAKA, T
UGAJIN, S
YOKOYAMA, S
[J]. CHEMISTRY LETTERS, 1988, (09) : 1571 - 1572
[14] VALENTINE D, 1978, SYNTHESIS-STUTTGART, P329

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