THE ADULT HUMAN CEREBELLUM IS A TARGET OF THE NEUROENDOCRINE SYSTEM INVOLVED IN THE CIRCADIAN TIMING

被引:35
作者
FAUTECK, JD
LERCHL, A
BERGMANN, M
MOLLER, M
FRASCHINI, F
WITTKOWSKI, W
STANKOV, B
机构
[1] UNIV MILAN,DEPT PHARMACOL,CHAIR CHEMOTHERAPY,I-20129 MILAN,ITALY
[2] UNIV COPENHAGEN,PANUM INST,INST MED ANAT,DK-2200 COPENHAGEN,DENMARK
[3] UNIV MUNSTER,INST NEUROPATHOL,D-48149 MUNSTER,GERMANY
[4] UNIV MUNSTER,INST REPROD MED,D-48149 MUNSTER,GERMANY
[5] UNIV MUNSTER,INST ANAT,D-48149 MUNSTER,GERMANY
关键词
HUMAN CEREBELLUM; MELATONIN; MELATONIN RECEPTOR; RECEPTOR AUTORADIOGRAPHY;
D O I
10.1016/0304-3940(94)90935-0
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
In an investigation aimed at comprehensive mapping of the adult human brain with respect to receptor sites for the pineal hormone melatonin, we consistently observed specific binding in the cerebellum. Autoradiography and in vitro binding analysis with I-125-labeled melatonin were used to examine the location and the properties of these binding sites. In all cerebellar lobes, highest-density specific binding was localized to the external zone of the molecular layer. The binding was rapid, saturable, displaceable, specific and of high affinity. Physiological concentrations of NaCl decreased the affinity, while presence of calcium ions promoted it. The non-hydrolyzable GTP analog. GTPS, inhibited binding in a dose-dependent manner and provoked a shift towards low affinity. The results strongly suggest that these binding sites may be functional melatonin receptors, and indicate that the adult human cerebellum is a target of melatonin, the pineal hormone involved in the control of the circadian timing.
引用
收藏
页码:60 / 64
页数:5
相关论文
共 27 条
[21]   PUTATIVE MELATONIN RECEPTORS IN A HUMAN BIOLOGICAL CLOCK [J].
REPPERT, SM ;
WEAVER, DR ;
RIVKEES, SA ;
STOPA, EG .
SCIENCE, 1988, 242 (4875) :78-81
[22]   2-SUBSTITUTED 5-METHOXY-N-ACYLTRYPTAMINES - SYNTHESIS, BINDING-AFFINITY FOR THE MELATONIN RECEPTOR, AND EVALUATION OF THE BIOLOGICAL-ACTIVITY [J].
SPADONI, G ;
STANKOV, B ;
DURANTI, A ;
BIELLA, G ;
LUCINI, V ;
SALVATORI, A ;
FRASCHINI, F .
JOURNAL OF MEDICINAL CHEMISTRY, 1993, 36 (25) :4069-4074
[23]   LOCALIZATION AND CHARACTERIZATION OF MELATONIN BINDING-SITES IN THE BRAIN OF THE RABBIT (ORYCTOLAGUS-CUNICULUS) BY AUTORADIOGRAPHY AND INVITRO LIGAND RECEPTOR-BINDING [J].
STANKOV, B ;
COZZI, B ;
LUCINI, V ;
CAPSONI, S ;
FAUTECK, J ;
FUMAGALLI, P ;
FRASCHINI, F .
NEUROSCIENCE LETTERS, 1991, 133 (01) :68-72
[24]   CHARACTERIZATION AND MAPPING OF MELATONIN RECEPTORS IN THE BRAIN OF 3 MAMMALIAN-SPECIES - RABBIT, HORSE AND SHEEP - A COMPARATIVE INVITRO BINDING STUDY [J].
STANKOV, B ;
COZZI, B ;
LUCINI, V ;
FUMAGALLI, P ;
SCAGLIONE, F ;
FRASCHINI, F .
NEUROENDOCRINOLOGY, 1991, 53 (03) :214-221
[25]  
STANKOV B, IN PRESS ADV PINEAL, V8
[26]   IODINATED MELATONIN - PREPARATION AND CHARACTERIZATION OF THE MOLECULAR-STRUCTURE BY MASS AND H-1-NMR SPECTROSCOPY [J].
VAKKURI, O ;
LAMSA, E ;
RAHKAMAA, E ;
RUOTSALAINEN, H ;
LEPPALUOTO, J .
ANALYTICAL BIOCHEMISTRY, 1984, 142 (02) :284-289
[27]   IODINATED MELATONIN MIMICS MELATONIN ACTION AND REVEALS DISCRETE BINDING-SITES IN FETAL BRAIN [J].
WEAVER, DR ;
NAMBOODIRI, MAA ;
REPPERT, SM .
FEBS LETTERS, 1988, 228 (01) :123-127