TETRAZOLES OF MANNO-FURANOSES AND RHAMNO-FURANOSES

被引：46

作者：

DAVIS, B

BRANDSTETTER, TW

SMITH, C

HACKETT, L

WINCHESTER, BG

FLEET, GWJ

机构：

[1] OXFORD CTR MOLEC SCI,DYSON PERRINS LAB,OXFORD OX1 3QY,ENGLAND

[2] GLAXO WELLCOME MED RES CTR,STEVENAGE SG1 2NY,HERTS,ENGLAND

[3] UNIV LONDON,INST CHILD DEV,LONDON WC1 1EH,ENGLAND

[4] UNIV LONDON,GREAT ORMOND ST HOSP CHILDREN,NHS TRUST,LONDON WC1 1EH,ENGLAND

来源：

TETRAHEDRON LETTERS | 1995年 / 36卷 / 41期

关键词：

D O I：

10.1016/0040-4039(95)01518-3

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthesis of tetrazoles derived from D-mannofuranose and both enantiomers of rhamnofuranose provides the first examples of tetrazole analogues of carbohydrates in the furanose form. The D-furanotetrazoles are potential mannosidase inhibitors whereas the L-rhamnotetrazole may interfere with the biosynthesis of cell walls of mycobacteria and provide a strategy for the treatment of tuberculosis and leprosy.

引用

页码：7507 / 7510

页数：4

共 12 条

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