TOTAL SYNTHESIS AND ABSOLUTE CONFIGURATION OF NATURAL MULTIFLORAMINES

被引：36

作者：

BROSSI, A

OBRIEN, J

TEITEL, S

机构：

[1] Chemische Forschungabteilung der Hoffmann-La Roche Inc, Nutley, New Jersey

来源：

HELVETICA CHIMICA ACTA | 1969年 / 52卷 / 03期

关键词：

D O I：

10.1002/hlca.19690520316

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The diphenol 1 was resolved into its antipodes and their absolute configuration was established. The levorotatory isomer R‐(−)‐1 was oxidized to the dienone R‐(−)‐6, which was rearranged to afford natural (−)‐multifloramine (R‐(−)‐7), thus establishing that the latter has the R‐configuration. By the same reaction sequences, the enantiomeric diphenol S‐(+)‐1 was transformed to provide (+)‐multifloramine (S‐(+)‐7) of the S‐configuration. Copyright © 1969 Verlag GmbH & Co. KGaA, Weinheim

引用

页码：678 / &

共 7 条

[1]

Arndt F., 1943, ORG SYNTH, VII, P165

[2] STRUCTURE AND SYNTHESIS OF HOMOAPORPHINES - A NEW GROUP OF 1-PHENETHYLISOQUINOLINE ALKALOIDS [J].