CONTRIBUTIONS OF LOW-THRESHOLD CALCIUM CURRENT AND ANOMALOUS RECTIFIER (IH) TO SLOW DEPOLARIZATIONS UNDERLYING BURST FIRING IN HUMAN NEOCORTICAL NEURONS INVITRO

被引：51

作者：

FOEHRING, RC

WATERS, RS

机构：

[1] Department of Anatomy and Neurobiology, University of Tennessee, Memphis, Memphis

来源：

NEUROSCIENCE LETTERS | 1991年 / 124卷 / 01期

关键词：

HUMAN NEOCORTEX; CALCIUM CURRENT; ANOMALOUS RECTIFICATION; BURST-FIRING; INTRACELLULAR RECORDING;

D O I：

10.1016/0304-3940(91)90812-8

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The slow depolarization that underlies the voltage-dependent burst-firing behavior of human neocortical neurons is mediated by a low-threshold calcium conductance in concert with the anomalous rectifier current, I(h). The slow depolarization could be elicited by depolarization from negative membrane potentials or as a rebound following hyperpolarization. The rebound depolarization was time- and voltage-dependent. Most of the slow depolarization was blocked by inorganic calcium blockers. The remainder of the depolarization and the 'sag' in the hyperpolarizing voltage responses were blocked by extracellular Cs+.

引用

页码：17 / 21

页数：5

共 23 条

[1] M-CURRENTS AND OTHER POTASSIUM CURRENTS IN BULLFROG SYMPATHETIC NEURONS [J].