SYNTHESIS AND ACTIVITY OF ENANTIOPURE (S)(M-NITROBENZOYL) ALANINE, POTENT KYNURENINE-3-HYDROXYLASE INHIBITOR

被引：22

作者：

NATALINI, B

MATTOLI, L

PELLICCIARI, R

CARPENEDO, R

CHIARUGI, A

MORONI, F

机构：

[1] UNIV PERUGIA,IST CHIM & TECNOL FARMACO,I-06123 PERUGIA,ITALY

[2] UNIV FLORENCE,DIPARTIMENTO FARMACOL PRECLIN & CLIN,I-50134 FLORENCE,ITALY

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1995年 / 5卷 / 14期

关键词：

D O I：

10.1016/0960-894X(95)00255-R

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The enantioselective synthesis of S(+)(m-nitrobenzoyl)alanine along with the inhibition of kynurenine-3-hydroxylase and kynureninase activity are reported.

引用

页码：1451 / 1454

页数：4

共 8 条

[1]

ITOH M, 1969, CHEM PHARM BULL, V17, P1679

[2] PREPARATION OF ARYLTRIBUTYLTIN HAVING ELECTRON-WITHDRAWING GROUP BY PALLADIUM CATALYZED REACTION OF HEXABUTYLDITIN WITH ARYL IODIDE [J].

KOSUGI, M ;

OHYA, T ;

MIGITA, T .

BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN, 1983, 56 (12) :3855-3856

[3] MODULATION OF QUINOLINIC AND KYNURENIC ACID CONTENT IN THE RAT-BRAIN - EFFECTS OF ENDOTOXINS AND NICOTINYLALANINE [J].

MORONI, F ;

RUSSI, P ;

GALLOMEZO, MA ;

MONETI, G ;

PELLICCIARI, R .

JOURNAL OF NEUROCHEMISTRY, 1991, 57 (05) :1630-1635

[4] STEREOSPECIFIC SYNTHESIS OF THE ENANTIOMERS OF NICOTINYLALANINE, A NEUROPROTECTING AGENT [J].

PELLICCIARI, R ;

GALLOMEZO, MA ;

NATALINI, B ;

AMER, AM .

TETRAHEDRON LETTERS, 1992, 33 (21) :3003-3004

[5] MODULATION OF THE KYNURENINE PATHWAY IN SEARCH FOR NEW NEUROPROTECTIVE AGENTS - SYNTHESIS AND PRELIMINARY EVALUATION OF (M-NITROBENZOYL)ALANINE, A POTENT INHIBITOR OF KYNURENINE-3-HYDROXYLASE [J].

PELLICCIARI, R ;

NATALINI, B ;

COSTANTINO, G ;

MAHMOUD, MR ;

MATTOLI, L ;

SADEGHPOUR, BM ;

MORONI, F ;

CHIARUGI, A ;

CARPENEDO, R .

JOURNAL OF MEDICINAL CHEMISTRY, 1994, 37 (05) :647-655

[6] FACILE SYNTHESIS OF L-KYNURENINE [J].

SALITURO, FG ;

MCDONALD, IA .

JOURNAL OF ORGANIC CHEMISTRY, 1988, 53 (26) :6138-6139

[7] THE PALLADIUM-CATALYZED CROSS-COUPLING REACTIONS OF ORGANOTIN REAGENTS WITH ORGANIC ELECTROPHILES [J].

STILLE, JK .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH, 1986, 25 (06) :508-523

[8]

Watson G.B., 1988, NEUROSCI RES COMMUN, V2, P169

← 1 →