IDENTIFICATION OF SIGNALING AND NON-SIGNALING BINDING CONTRIBUTIONS TO ENZYME REACTIVITY - ALTERNATIVE COMBINATIONS OF BINDING INTERACTIONS PROVIDE FOR CHANGE IN TRANSITION-STATE GEOMETRY IN REACTIONS OF PAPAIN

被引：31

作者：

KOWLESSUR, D

TOPHAM, CM

THOMAS, EW

ODRISCOLL, M

TEMPLETON, W

BROCKLEHURST, K

机构：

[1] UNIV LONDON ST BARTHOLOMEWS HOSP, COLL MED, DEPT BIOCHEM, CHARTERHOUSE SQ, LONDON EC1M 6BQ, ENGLAND

[2] UNIV SALFORD, DEPT BIOL SCI, SALFORD M5 4WT, LANCS, ENGLAND

来源：

BIOCHEMICAL JOURNAL | 1989年 / 258卷 / 03期

关键词：

D O I：

10.1042/bj2580755

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

引用

页码：755 / 764

页数：10

共 35 条

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[10] REACTIVITIES OF VARIOUS PROTONIC STATES IN REACTIONS OF PAPAIN AND OF L-CYSTEINE WITH 2,2'-DIPYRIDYL DISULFIDE AND WITH 4,4'-DIPYRIDYL DISULFIDE - EVIDENCE FOR NUCLEOPHILIC REACTIVITY IN UNIONIZED THIOL GROUP OF CYSTEINE-25 RESIDUE OF PAPAIN OCCASSIONED BY ITS INTERACTION WITH HISTIDINE-159-ASPARAGINE-175 HYDROGEN-BONDED SYSTEM
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