EUROPIUM (S,S)-ETHYLENEDIAMINE-N,N'-DISUCCINATE AS A CHIRAL LANTHANIDE SHIFT-REAGENT FOR AQUEOUS-SOLUTIONS

被引：24

作者：

KIDO, J

OKAMOTO, Y

BRITTAIN, HG

机构：

[1] BRISTOL MYERS SQUIBB CO,PHARMACEUT RES INST,POB 191,NEW BRUNSWICK,NJ 08903

[2] POLYTECH INST NEW YORK,DEPT CHEM,333 JAY ST,BROOKLYN,NY 11201

[3] POLYTECH INST NEW YORK,POLYMER RES INST,BROOKLYN,NY 11201

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1991年 / 56卷 / 04期

关键词：

D O I：

10.1021/jo00004a014

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The title compound has been utilized for H-1 NMR spectral resolution of enantiomeric amino acids in aqueous solutions. For the alpha-protons of D,L-phenylglycine, an enantiomeric shift difference, DELTA-DELTA-delta = 0.4 ppm, was observed at an Eu(EDDS):substrate ratio of 0.3. Association constants between Eu(EDDS) and D,L-phenylglycine were found to be different for each isomer, K(L) = 3.7 and K(D) = 6.1. Spectral resolution of other amino acids including alanine, serine, threonine, and phenylalanine was also achieved.

引用

页码：1412 / 1415

页数：4

共 15 条

[11]

RABER DJ, 1983, ORG MAGN RESONANCE, V20, P125

[12]

REUBEN J, 1980, J AM CHEM SOC, V102, P2232, DOI 10.1021/ja00527a015

[13] CIRCULARLY POLARIZED LUMINESCENCE STUDIES OF THE TERNARY COMPLEXES FORMED BY TB(III) WITH (S,S)-ETHYLENEDIAMINE-N,N'-DISUCCINIC ACID AND ACHIRAL SUBSTRATE LIGANDS [J].