BEHAVIORAL AND NEURO-ENDOCRINE EFFECTS OF LOW-DOSE ET-495 - ANTAGONISM BY HALOPERIDOL

被引：15

作者：

ANGRIST, B

AIN, M

ROTROSEN, J

GERSHON, S

HALPERN, FS

SACHAR, EJ

机构：

[1] NYU, SCH MED, DEPT PSYCHIAT, NEW YORK, NY 10016 USA

[2] COLUMBIA UNIV COLL PHYS & SURG, NEW YORK, NY 10032 USA

[3] NEW YORK STATE PSYCHIAT INST, NEW YORK, NY 10032 USA

来源：

JOURNAL OF NEURAL TRANSMISSION | 1979年 / 44卷 / 04期

关键词：

D O I：

10.1007/BF01250321

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Low doses of the dopamine agonist ET-495 were administered to non-psychotic volunteer subjects by slow intravenous infusion, followed by a bolus of 1.5-2.5 mg haloperidol. ET-495 caused progressive dysphoria and sedation (in some cases, light sleep), effects believed to be mediated by dopaminergic inhibition. However, ET-495 also elevated growth hormone and suppressed prolactin, typical responses to dopamine agonist activity. Haloperidol reversed both the sedation and prolactin suppression induced by ET-495. These findings suggest: (1) that the sedation and hormonal responses were produced by stimulation of dopamine receptors; (2) that neurotransmitter systems mediating behavioral and neuroendocrine regulation may have differential neuropharmacological characteristics. © 1979 Springer-Verlag.

引用

页码：249 / 262

页数：14