RECOVERY OF MURINE MYELOPOIESIS AFTER CYTOSTATIC REDUCTION BY ARA-C - EFFECT OF BACITRACIN-INDUCED CHANGES IN THE INTESTINAL MICROFLORA AND INFLUENCE OF TIMING

被引：5

作者：

DAENEN, S ^{[1
]}

GORIS, H ^{[1
]}

DEBOER, F ^{[1
]}

HALIE, MR ^{[1
]}

VANDERWAAIJ, D ^{[1
]}

机构：

[1] UNIV GRONINGEN,MED MICROBIOL LAB,9700 AB GRONINGEN,NETHERLANDS

来源：

LEUKEMIA RESEARCH | 1991年 / 15卷 / 11期

关键词：

ANTIBIOTICS; COLONY-FORMING UNIT (CFU); COLONY-STIMULATING FACTOR (CSF); ENDOTOXIN; GRAM-NEGATIVE BACTERIA; INTESTINAL FLORA;

D O I：

10.1016/0145-2126(91)90106-4

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The influence of intestinal flora modulation by oral bacitracin on the recovery of myelopoiesis after Ara-C was studied in C3H/Law mice. Bacitracin resulted in a 3-5 log increase of Gram-negative bacteria and a 10-fold increase of the intestinal endotoxin concentration. Initiation of bacitracin before Ara-C stimulated the initial rebound increase of colony-forming units for granulocytes and macrophages (CFU-GM) from 23.2 +/- 1.3 to 28.4 +/- 1.4 x 10(3) per femur. Starting the bacitracin after Ara-C advanced the second phase of the rebound CFU-GM increase with 6 days. An important role in the recovery of myelopoiesis after cytostatic drugs in C3H/Law mice is suggested for the intestinal Gram-negative microflora, probably mediated by bacterial endotoxin.

引用

页码：1013 / 1018

页数：6