GLUTAMINE-SYNTHETASE (GS) EXPRESSION IS REDUCED IN SENILE DEMENTIA OF THE ALZHEIMER-TYPE

被引：81

作者：

LEPRINCE, G

DELAERE, P

FAGES, C

LEFRANCOIS, T

TOURET, M

SALANON, M

TARDY, M

机构：

[1] HOP HENRI MONDOR,FAC MED,INSERM,U421,F-94010 CRETEIL,FRANCE

[2] HOP LA PITIE SALPETRIERE,ASSOC CLAUDE BERNARD,INSERM,U360,LAB NEUROPATHOL RAYMOND ESCOUROLLE,F-75651 PARIS 13,FRANCE

[3] UNIV LYON 1,DEPT EXPTL MED,F-69373 LYON 08,FRANCE

来源：

NEUROCHEMICAL RESEARCH | 1995年 / 20卷 / 07期

关键词：

BLESSED TEST SCORE; ASTROCYTE; CLASSICAL SENILE PLAQUE; BETA-A4 CLASSICAL DEPOSITS;

D O I：

10.1007/BF00969698

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Glutamine synthetase (GS), a metabolic marker of the mature astrocyte, was investigated in the temporal neocortex of postmortem brain samples of 8 cases, either not demented or affected by senile dementia of the Alzheimer type. A negative correlation between the GS protein level and the density of both classical beta A4 deposits and senile plaques was evidenced. Such a correlation for GS underlies a dysfunction of the astroglial metabolism and particularly of the glutamate and ammonia neutralization. Since GS is sensitive to oxidative lesioning, the changes in GS level that were observed, occurring at the posttranslational stage, might reflect oxidative damage and have severe consequences on the pathological cascade of events.

引用

页码：859 / 862

页数：4

共 27 条

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