LONG-TERM ASTROGLIAL REACTION TO SEROTONERGIC FIBER DEGENERATION

被引：14

作者：

FAGES, C

LEPRINCE, G

DIDIERBAZES, M

ROLLAND, B

HARDIN, H

TARDY, M

机构：

[1] HOP HENRI MONDOR,INSERM,U282,F-94010 CRETEIL,FRANCE

[2] FAC MED ALEXIS CARREL,INSERM,CJF9010,F-69372 LYON,FRANCE

来源：

BRAIN RESEARCH | 1994年 / 639卷 / 01期

关键词：

ASTROCYTE REACTIVITY; SEROTONIN; 5,7-DIHYDROXYTRYPTAMINE; GLIAL FIBRILLARY ACIDIC PROTEIN; GLUTAMINE SYNTHETASE;

D O I：

10.1016/0006-8993(94)91777-9

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Glial fibrillary acidic protein (GFAP) and glutamine synthetase (GS) expression were analysed by Western and Northern blotting in the hippocampus, the frontal and occipital cortex, and the cerebellum of the adult rat, as a manifestation of the astroglial reaction, 2 and 3 months after 5,7-dihydroxytryptamine injection into the lateral ventricule. 5HT injury stimulated GFAP and GS expression in a temporally and regionally specific fashion. At 2 months postlesion, the GFAP-mRNA and GFAP levels appeared enhanced but returned to control levels at 3 months. The GFAP-mRNA and GS-mRNA levels increased in the frontal cortex at 3 months. Such a delayed astroglial reactivity might implicate astrocytes in neurodegenerative disorders.

引用

页码：161 / 166

页数：6

共 30 条

[1] WHAT IS THE NATURE OF THE ROLE OF THE SEROTONERGIC NERVOUS-SYSTEM IN LEARNING AND MEMORY - PROSPECTS FOR DEVELOPMENT OF AN EFFECTIVE TREATMENT STRATEGY FOR SENILE DEMENTIA [J].