MEMBRANE-ALTERATIONS AS CAUSES OF IMPAIRED SIGNAL-TRANSDUCTION IN ALZHEIMERS-DISEASE AND AGING

被引：151

作者：

ROTH, GS

JOSEPH, JA

MASON, RP

机构：

[1] TUFTS UNIV, USDA ARS, CTR HUMAN NUTR, BOSTON, MA 02111 USA

[2] ALLEGHENY SINGER RES INST, NEUROSCI RES CTR, PITTSBURGH, PA 15212 USA

来源：

TRENDS IN NEUROSCIENCES | 1995年 / 18卷 / 05期

关键词：

D O I：

10.1016/0166-2236(95)93902-A

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Changes in cell-membrane composition in normal aging and in Alzheimer's and other age-related diseases appear to result in impaired neurotransmitter-triggered signal transduction. The impaired signal transduction seems to be related to dysfunctions in the coupling of G proteins to their receptors and effecters. Direct demonstration of altered physiochemical properties of brain tissue of patients with Alzheimer's disease has been achieved by small-angle X-ray diffraction. In this disease, thinner membranes correlate with a 30% decrease in moles of cholesterol: phospholipid. Such changes can affect directly the coupling and uncoupling properties of G proteins, and can account for signal transduction deficits. These findings offer a complementary alternative to the beta-amyloid hypothesis, and an opportunity to consider new types of therapeutic interventions.

引用

页码：203 / 206

页数：4

共 57 条

[51] AMYLOID PRECURSOR PROTEIN IN THE CEREBRAL-CORTEX IS RAPIDLY AND PERSISTENTLY INDUCED BY LOSS OF SUBCORTICAL INNERVATION [J].