TRYPTAMINE-INDUCED DRUG EFFECTS INSENSITIVE TO SEROTONINERGIC ANTAGONISTS - EVIDENCE OF SPECIFIC TRYPTAMINERGIC RECEPTOR STIMULATION

被引：37

作者：

QUOCK, RM ^{[1
]}

WEICK, BG ^{[1
]}

机构：

[1] UNIV WASHINGTON,SCH MED,DEPT PHARMACOL,SEATTLE,WA 98195

来源：

JOURNAL OF PHARMACY AND PHARMACOLOGY | 1978年 / 30卷 / 05期

关键词：

D O I：

10.1111/j.2042-7158.1978.tb13229.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The drug effects of tryptamine and 5‐hydroxytryptophan (5‐HTP) in the rabbit were compared following monoamine oxidase inhibition and various drug pretreatments. Both agents evoked hyperthermia and behavioural excitation; tryptamine but not 5‐HTP also produced forepaw clonic activity. Serotoninergic receptor blockers abolished the effects of 5‐HTP but only weakly influenced tryptamine responses. Both tryptamine and 5‐HTP effects were potentiated by fluoxetine. Methergoline, a putative tryptaminergic receptor blocker, antagonized tryptamine‐induced hyperthermia and forepaw clonus but did not influence 5‐HTP responses. It is postulated that while 5‐HTP produces its effects through a serotoninergic mechanism, some of the responses to tryptamine result from activation of a specific tryptamine‐sensitive mechanism. 1978 Royal Pharmaceutical Society of Great Britain

引用

页码：280 / 283

页数：4

共 30 条

[21]

POURRIAS B, 1975, J PHARMACOL-PARIS, V6, P153

[22]

RUBIN B, 1964, ARCHS INT PHARMACODY, V152, P131

[23]

Saavedra J M, 1974, Adv Biochem Psychopharmacol, V10, P135

[24]

SHELLENBERGER MK, 1967, J PHARMACOL EXP THER, V158, P219

[25]

TEDESCHI DH, 1959, J PHARMACOL EXP THER, V126, P223

[26] EFFECTS OF TRYPTAMINE ON CONDITIONED AVOIDANCE-RESPONSE IN RATS [J].

VOGEL, WH ;

COHEN, I .

BRAIN RESEARCH, 1977, 122 (01) :162-164

[27]

WINTER JC, 1968, J PHARMACOL EXP THER, V162, P286

[28]

WOLLEY DW, 1953, J BIOL CHEM, V203, P69

[29] SELECTIVE INHIBITOR OF SEROTONIN UPTAKE - LILLY 110140, 3-(PARA-TRIFLUOROMETHYLPHENOXY)-N-METHYL-3-PHENYLPROPYLAMINE [J].

WONG, DT ;

HORNG, JS ;

BYMASTER, FP ;

HAUSER, KL ;

MOLLOY, BB .

LIFE SCIENCES, 1974, 15 (03) :471-479

[30]

WOOLLEY DW, 1957, J PHARMACOL EXP THER, V121, P13

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