PHOSPHINATO(DIALKYLMETHYL)PHOSPHONATES AS PYROPHOSPHATE MIMICS - SYNTHESIS AND SQUALENE SYNTHETASE INHIBITORY ACTIVITY OF FARNESYL PHOSPHINATO(DIALKYLMETHYL)PHOSPHONATES

被引：12

作者：

PRASHAD, M ^{[1
]}

TOMESCH, JC ^{[1
]}

WAREING, JR ^{[1
]}

SCALLEN, T ^{[1
]}

机构：

[1] UNIV NEW MEXICO,SCH MED,DEPT BIOCHEM,ALBUQUERQUE,NM 87131

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 1993年 / 28卷 / 06期

关键词：

SQUALENE SYNTHETASE; PHOSPHINATO(DIALKYLMETHYL)PHOSPHONATE; PYROPHOSPHATE MIMICS; CHOLESTEROL BIOSYNTHESIS PATHWAY; ENZYME INHIBITORS;

D O I：

10.1016/0223-5234(93)90022-7

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The synthesis and squalene synthetase inhibitory activity of farnesyl phosphinato(dialkylmethyl)phosphonates has been described. The phosphinato(dimethylmethyl)phosphonate group provided a suitable mimic of pyrophosphate.

引用

页码：527 / 531

页数：5

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