PHENAZOVIRIDIN, A NOVEL FREE-RADICAL SCAVENGER FROM STREPTOMYCES SP - TAXONOMY, FERMENTATION, ISOLATION, STRUCTURE ELUCIDATION AND BIOLOGICAL PROPERTIES

被引：35

作者：

KATO, S

SHINDO, K

YAMAGISHI, Y

MATSUOKA, M

KAWAI, H

MOCHIZUKI, J

机构：

[1] Research Laboratory, Kirin Brewery Co., Ltd., Takasaki

来源：

JOURNAL OF ANTIBIOTICS | 1993年 / 46卷 / 10期

关键词：

D O I：

10.7164/antibiotics.46.1485

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Phenazoviridin is a newly discovered free radical scavenger from microorganisms. It was isolated from the culture of Streptomyces sp. HR04. The structure of phenazoviridin was determined as 6-(3-methyl-2-butenyl)phenazine-1-carboxylic acid 6-deoyx-alpha-L-talopyranose ester on the basis of its spectroscopic and physico-chemical properties. The novel substance showed strong inhibitory activity against lipid peroxidation in rat brain homogenate and exhibited antihypoxic activity in mice.

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页码：1485 / 1493

页数：9

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