2,4-DIAMINO-5-BENZYLPYRIMIDINES AND ANALOGS AS ANTIBACTERIAL AGENTS .12. 1,2-DIHYDROQUINOLYLMETHYL ANALOGS WITH HIGH-ACTIVITY AND SPECIFICITY FOR BACTERIAL DIHYDROFOLATE-REDUCTASE

被引:229
作者
JOHNSON, JV [1 ]
RAUCKMAN, BS [1 ]
BACCANARI, DP [1 ]
ROTH, B [1 ]
机构
[1] WELLCOME RES LABS,RES TRIANGLE PK,NC 27709
关键词
D O I
10.1021/jm00128a042
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
引用
收藏
页码:1942 / 1949
页数:8
相关论文
共 27 条
[1]  
AMBRUS D, Patent No. 157370
[2]   INHIBITION OF DIHYDROFOLATE-REDUCTASE - EFFECT OF REDUCED NICOTINAMIDE ADENINE-DINUCLEOTIDE PHOSPHATE ON THE SELECTIVITY AND AFFINITY OF DIAMINOBENZYLPYRIMIDINES [J].
BACCANARI, DP ;
DALUGE, S ;
KING, RW .
BIOCHEMISTRY, 1982, 21 (20) :5068-5075
[3]   DIHYDROFOLATE-REDUCTASE HYSTERESIS AND ITS EFFECT ON INHIBITOR BINDING ANALYSES [J].
BACCANARI, DP ;
JOYNER, SS .
BIOCHEMISTRY, 1981, 20 (07) :1710-1716
[4]  
BOLIN JT, 1982, J BIOL CHEM, V257, P13650
[5]   TIGHT-BINDING INHIBITORS .1. KINETIC-BEHAVIOR [J].
CHA, S .
BIOCHEMICAL PHARMACOLOGY, 1975, 24 (23) :2177-2185
[6]   CRYSTALLOGRAPHIC INVESTIGATION OF THE COOPERATIVE INTERACTION BETWEEN TRIMETHOPRIM, REDUCED COFACTOR AND DIHYDROFOLATE-REDUCTASE [J].
CHAMPNESS, JN ;
STAMMERS, DK ;
BEDDELL, CR .
FEBS LETTERS, 1986, 199 (01) :61-67
[7]  
CHAMPNESS JN, UNPUB
[8]   2,4-DIAMINO-5-BENZYLPYRIMIDINES AND ANALOGS AS ANTIBACTERIAL AGENTS .11. QUINOLYLMETHYL ANALOGS WITH BASIC SUBSTITUENTS CONVEYING SPECIFICITY [J].
DAVIS, SE ;
RAUCKMAN, BS ;
CHAN, JH ;
ROTH, B .
JOURNAL OF MEDICINAL CHEMISTRY, 1989, 32 (08) :1936-1942
[9]  
ELDERFIELD RC, 1952, HETEROCYCL COMPOUNDS, V4, P271
[10]   STRUCTURE OF DIMER OF 2,2,4-TRIMETHYL-1,2-DIHYDROQUINOLINE [J].
ELLIOTT, IW ;
DUNATHAN, HC .
TETRAHEDRON, 1963, 19 (06) :833-&