SYNERGISTIC INHIBITION OF REPLICATION OF HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1, INCLUDING THAT OF A ZIDOVUDINE-RESISTANT ISOLATE, BY ZIDOVUDINE AND 2',3'-DIDEOXYCYTIDINE INVITRO

被引：60

作者：

ERON, JJ

JOHNSON, VA

MERRILL, DP

CHOU, TC

HIRSCH, MS

机构：

[1] MASSACHUSETTS GEN HOSP,INFECT DIS UNIT,BOSTON,MA 02114

[2] HARVARD UNIV,SCH MED,BOSTON,MA 02115

[3] MEM SLOAN KETTERING CANC CTR,BIOCHEM PHARMACOL LAB,NEW YORK,NY 10021

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1992年 / 36卷 / 07期

关键词：

D O I：

10.1128/AAC.36.7.1559

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The combination of zidovudine (AZT) and 2',3'-dideoxycytidine synergistically inhibits human immunodeficiency virus type 1 (HIV-1) replication in vitro with AZT-sensitive and AZT-resistant clinical isolates and HIV-1IIIB. Synergy was,determined by the median-effect principle and isobologram techniques. Cytotoxicity of the agents was not observed. Clinical trials are ongoing to define the combination's role in HIV-1 therapy.

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页码：1559 / 1562

页数：4

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