SYNERGISTIC INHIBITION OF REPLICATION OF HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1, INCLUDING THAT OF A ZIDOVUDINE-RESISTANT ISOLATE, BY ZIDOVUDINE AND 2',3'-DIDEOXYCYTIDINE INVITRO

被引：60

作者：

ERON, JJ

JOHNSON, VA

MERRILL, DP

CHOU, TC

HIRSCH, MS

机构：

[1] MASSACHUSETTS GEN HOSP,INFECT DIS UNIT,BOSTON,MA 02114

[2] HARVARD UNIV,SCH MED,BOSTON,MA 02115

[3] MEM SLOAN KETTERING CANC CTR,BIOCHEM PHARMACOL LAB,NEW YORK,NY 10021

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1992年 / 36卷 / 07期

关键词：

D O I：

10.1128/AAC.36.7.1559

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The combination of zidovudine (AZT) and 2',3'-dideoxycytidine synergistically inhibits human immunodeficiency virus type 1 (HIV-1) replication in vitro with AZT-sensitive and AZT-resistant clinical isolates and HIV-1IIIB. Synergy was,determined by the median-effect principle and isobologram techniques. Cytotoxicity of the agents was not observed. Clinical trials are ongoing to define the combination's role in HIV-1 therapy.

引用

收藏

页码：1559 / 1562

页数：4

相关论文

共 36 条

[11]

FISCHL MA, 1991, J ACQ IMMUN DEF SYND, V4, P1

[12] A RANDOMIZED CONTROLLED TRIAL OF A REDUCED DAILY DOSE OF ZIDOVUDINE IN PATIENTS WITH THE ACQUIRED-IMMUNODEFICIENCY-SYNDROME [J].

FISCHL, MA ;

PARKER, CB ;

PETTINELLI, C ;

WULFSOHN, M ;

HIRSCH, MS ;

COLLIER, AC ;

ANTONISKIS, D ;

HO, M ;

RICHMAN, DD ;

FUCHS, E ;

MERIGAN, TC ;

REICHMAN, RC ;

GOLD, J ;

STEIGBIGEL, N ;

LEOUNG, GS ;

RASHEED, S ;

TSIATIS, A .

NEW ENGLAND JOURNAL OF MEDICINE, 1990, 323 (15) :1009-1014

[13] HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 POL GENE-MUTATIONS WHICH CAUSE DECREASED SUSCEPTIBILITY TO 2',3'-DIDEOXYCYTIDINE [J].

FITZGIBBON, JE ;

HOWELL, RM ;

HABERZETTL, CA ;

SPERBER, SJ ;

GOCKE, DJ ;

DUBIN, DT .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1992, 36 (01) :153-157

[14] SYNERGISTIC INHIBITION OF HUMAN-IMMUNODEFICIENCY-VIRUS INVITRO BY AZIDOTHYMIDINE AND RECOMBINANT ALPHA-A INTERFERON [J].

HARTSHORN, KL ;

VOGT, MW ;

CHOU, TC ;

BLUMBERG, RS ;

BYINGTON, R ;

SCHOOLEY, RT ;

HIRSCH, MS .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1987, 31 (02) :168-172

[15] QUANTITATION OF HUMAN IMMUNODEFICIENCY VIRUS TYPE-1 IN THE BLOOD OF INFECTED PERSONS [J].

HO, DD ;

MOUDGIL, T ;

ALAM, M .

NEW ENGLAND JOURNAL OF MEDICINE, 1989, 321 (24) :1621-1625

[16]

JOHNSON VA, 1989, ANTIVIRAL CHEMOTHERAPY : NEW DIRECTIONS FOR CLINICAL APPLICATION AND RESEARCH, VOL 2, P275

[17] 2-DRUG COMBINATIONS OF ZIDOVUDINE, DIDANOSINE, AND RECOMBINANT INTERFERON-ALPHA A INHIBIT REPLICATION OF ZIDOVUDINE-RESISTANT HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 SYNERGISTICALLY INVITRO [J].

JOHNSON, VA ;

MERRILL, DP ;

VIDELER, JA ;

CHOU, TC ;

BYINGTON, RE ;

ERON, JJ ;

DAQUILA, RT ;

HIRSCH, MS .

JOURNAL OF INFECTIOUS DISEASES, 1991, 164 (04) :646-655

[18]

JOHNSON VA, 1990, TECHNIQUES HIV RES, P71

[19]

JOHNSTON VA, 1990, TECHNIQUES HIV RES, P95

[20] 2',3'-DIDEOXYINOSINE (DDI) IN PATIENTS WITH THE ACQUIRED-IMMUNODEFICIENCY-SYNDROME OR AIDS-RELATED COMPLEX - A PHASE-I TRIAL [J].

LAMBERT, JS ;

SEIDLIN, M ;

REICHMAN, RC ;

PLANK, CS ;

LAVERTY, M ;

MORSE, GD ;

KNUPP, C ;

MCLAREN, C ;

PETTINELLI, C ;

VALENTINE, FT ;

DOLIN, R .

NEW ENGLAND JOURNAL OF MEDICINE, 1990, 322 (19) :1333-1340

← 1 2 3 4 →