INFLUENCE OF GLUTATHIONE CONJUGATION ON THE IMMUNOGENICITY OF DINITROPHENYL DERIVATIVES IN THE RAT

被引：14

作者：

TINGLE, MD ^{[1
]}

CLARKE, JB ^{[1
]}

KITTERINGHAM, NR ^{[1
]}

PARK, BK ^{[1
]}

机构：

[1] UNIV LIVERPOOL,DEPT PHARMACOL & THERAPEUT,LIVERPOOL L69 3BX,ENGLAND

来源：

INTERNATIONAL ARCHIVES OF ALLERGY AND APPLIED IMMUNOLOGY | 1990年 / 91卷 / 02期

基金：

英国惠康基金;

关键词：

D O I：

10.1159/000235108

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

The role of metabolic detoxication (glutathione conjugation) in the humoral response to three model haptens, dinitrofluorobenzene (DNFB), dinitrochlorobenzene (DNCB) and dinitrobenzenesulphonate (DNBS), was investigated in male Wistar rats. All three haptens produced a measurable anti-dinitrophenyl IgG antibody response over a wide dose range (2.7 nmol/kg to 0.27 mmol/kg) given for 4 days. A significant difference in antibody titre was only observed at the highest dose (DNFB > DNCB = DNBS), despite a marked difference in reactivity towards a protein carrier (albumin) and N-acetyl-lysine in vitro. These observations can be partly explained by the fact that the most reactive hapten (DNFB) conjugates most rapidly with glutathione in vitro and in vivo. © 1990 S. Karger AG, Basel.

引用

页码：160 / 165

页数：6

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