PLASMA ZINC AND COPPER CONCENTRATIONS IN RHEUMATOID-ARTHRITIS - INFLUENCE OF DIETARY FACTORS AND DISEASE-ACTIVITY

被引：36

作者：

HONKANEN, VEA

LAMBERG-ALLARDT, CH

VESTERINEN, MK

LEHTO, JH

WESTERMARCK, TW

METSAKETELA, TK

MUSSALORAUHAMAA, MH

KONTTINEN, YT

机构：

[1] HELSINKI CENT INST MENTALLY RETARDED, KIRKKONUMMI, FINLAND

[2] UNIV TAMPERE, DEPT BIOMED, TAMPERE, FINLAND

[3] UNIV HELSINKI, ENDOCRINE RES LAB, SF-00100 HELSINKI 10, FINLAND

[4] UNIV HELSINKI, DEPT NUTR SCI, SF-00100 HELSINKI 10, FINLAND

[5] UNIV HELSINKI, DEPT PUBL HLTH, SF-00100 HELSINKI 10, FINLAND

来源：

AMERICAN JOURNAL OF CLINICAL NUTRITION | 1991年 / 54卷 / 06期

关键词：

RHEUMATOID ARTHRITIS; DIET; ZINC; COPPER;

D O I：

10.1093/ajcn/54.6.1082

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

Forty patients with rheumatoid arthritis performed a thorough 7-d diet recording. The food diaries were analyzed together with clinical and laboratory data by means of stepwise multiple linear regression to clarify the effects of both diet and the inflammatory disorder on the plasma concentrations of zinc and copper. The patients' daily dietary intakes of zinc and copper (24.3 +/- 7.54 and 3.48 +/- 1.55 mg/MJ) were comparable to the corresponding intakes in the ordinary Finnish diet (24.0 and 3.68 mg/MJ). In multivariate analyses the best predictors of plasma trace elements were the measures of disease activity and not the dietary factors. As an exception to this, there was a strong correlation between plasma copper-copper intake ratio and zinc intake both in univariate (r = -0.638, P < 0.001) and multivariate analysis. This suggests that zinc depresses copper absorption with intakes in normal, physiological ranges.

引用

页码：1082 / 1086

页数：5