ACTIVATION OF THE 92-KDA TYPE-IV COLLAGENASE BY TISSUE KALLIKREIN

被引:83
作者
DESRIVIERES, S [1 ]
HE, L [1 ]
PEYRI, N [1 ]
SORIA, C [1 ]
LEGRAND, Y [1 ]
MENASHI, S [1 ]
机构
[1] HOP ST LOUIS,INSERM,UNITE 353,1 AVE CLAUDE VELLEFAUX,F-75010 PARIS,FRANCE
关键词
D O I
10.1002/jcp.1041570319
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Type IV collagenases are secreted as latent 92 and 72 kDa proenzymes which are then activated extracellularly. The mechanisms by which they are activated in vivo are not clear. We have studied the activation of porcine endothelial cell type IV collagenases by tissue and plasma kallikrein, and found that tissue kallikrein was a very efficient activator of the 92 kDa type IV collagenase. Enzyme cleavage was observed at concentrations of tissue kallikrein as low as 0.1 mug/ml. Plasma kallikrein had no effect. By comparison, plasmin, which has been proposed to be the physiological activator of interstitial collagenase and stromelysin, and elastase were much less effective, and high concentrations (plasmin at 100-200 mug/ml and elastase at 20 mug/ml) were required to cause only a limited cleavage which was not associated with an increase in activity, as observed by the gelatin-gel lysis assay. In addition tissue kallikrein was found by immunohistochemistry to be present in the extracellular matrix of the intima of porcine aortic vessel wall. These findings suggest that tissue kallikrein can be a potential activator of the 92 kDa type IV collagenase in vivo. (C) 1993 Wiley-Liss, Inc.
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页码:587 / 593
页数:7
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