SECRETORY AND MOTOR ACTIVITIES AT THE GASTRODUODENAL JUNCTION IN DOGS

Motor patterns of the canine gastroduodenal junction were investigated by electromyography under different secretory conditions: enhancement by pentagastrin and reduction by proglumide, cimetidine or CMN 131. The intravenous administration of these antisecretory agents did not affect the spiking activity or the slow-wave frequency of the antrum and duodenum, with the exception of CMN 131 which induced duodenal hyperactivity. Pentagastrin slowly infused intravenously increased the frequency of antral slow waves and spiking activity by 25 and 30% respectively. The simultaneous infusion of proglumide or CMN 131 significantly reduced this antral hypermotility. It was concluded that gastroduodenal motility was not affected by a reduction in acid secretion and it is suggested that the hypermotility observed during pentagastrin infusion may be a specific effect unrelated to increased acid secretion. © 1979 Elsevier Scientific Publishing Company.