ESTIMATION AND DETERMINATION OF STEROID SOLUBILITY IN SUPERCRITICAL CARBON-DIOXIDE

被引：17

作者：

DEAN, JR

KANE, M

KHUNDKER, S

DOWLE, C

TRANTER, RL

JONES, P

机构：

[1] ICI PLC,WILTON MAT RES CTR,MIDDLESBROUGH TS6 8JE,CLEVELAND,ENGLAND

[2] GLAXO GRP RES LTD,DURHAM DL12 8DT,ENGLAND

[3] PFIZER LTD,CENT RES,SANDWICH CT13 9NJ,KENT,ENGLAND

来源：

ANALYST | 1995年 / 120卷 / 08期

关键词：

STEROID SOLUBILITY; SUPERCRITICAL CARBON DIOXIDE; SOLUBILITY PREDICTION; SOLUBILITY PARAMETER; HYDROPHOBICITY; LOG P;

D O I：

10.1039/an9952002153

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

The solubility of ten steroids in supercritical carbon dioxide is. reported over a range of temperatures (35-100 degrees C) and pressures (84-231 kg cm(-2)). The solubility of testosterone, determined in this work, compares favourably with solubility data previously reported. The use of the solubility parameter and a hydrophobicity term (log P), has been shown to provide a qualitative estimate of steroid solubility.

引用

收藏

页码：2153 / 2157

页数：5

相关论文

共 22 条

[1] ESTIMATION OF SOLUBILITIES IN SUPERCRITICAL CARBON-DIOXIDE - A CORRELATION FOR THE PENG-ROBINSON INTERACTION PARAMETERS [J].

BARTLE, KD ;

CLIFFORD, AA ;

SHILSTONE, GF .

JOURNAL OF SUPERCRITICAL FLUIDS, 1992, 5 (03) :220-225

[2]

BARTLE KD, 1990, J CHROMATOGR, V57, P459

[3] PARTITIONING OF ORGANIC-COMPOUNDS IN OCTANOL-WATER SYSTEMS [J].

CHIOU, CT ;

SCHMEDDING, DW ;

MANES, M .

ENVIRONMENTAL SCIENCE & TECHNOLOGY, 1982, 16 (01) :4-10

[4] DETERMINATION OF OCTANOL WATER PARTITION-COEFFICIENTS FOR HYDROPHOBIC ORGANIC-CHEMICALS WITH THE SLOW-STIRRING METHOD [J].

DEBRUIJN, J ;

BUSSER, F ;

SEINEN, W ;

HERMENS, J .

ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY, 1989, 8 (06) :499-512

[5] METHOD FOR ESTIMATING BOTH SOLUBILITY PARAMETERS AND MOLAR VOLUMES OF LIQUIDS [J].

FEDORS, RF .

POLYMER ENGINEERING AND SCIENCE, 1974, 14 (02) :147-154

[6] ATOMIC PHYSICOCHEMICAL PARAMETERS FOR 3-DIMENSIONAL STRUCTURE DIRECTED QUANTITATIVE STRUCTURE-ACTIVITY-RELATIONSHIPS .3. MODELING HYDROPHOBIC INTERACTIONS [J].

GHOSE, AK ;

PRITCHETT, A ;

CRIPPEN, GM .

JOURNAL OF COMPUTATIONAL CHEMISTRY, 1988, 9 (01) :80-90

[7] DENSE GAS CHROMATOGRAPHY AT PRESSURES TO 2000 ATMOSPHERES [J].

GIDDINGS, JC ;

MYERS, MN ;

KING, JW .

JOURNAL OF CHROMATOGRAPHIC SCIENCE, 1969, 7 (05) :276-&

[8]

Hansch C., 1979, SUBSTITUENT CONSTANT

[9] PRINCIPLES OF METHOD SELECTION IN PARTITION STUDIES [J].

HERSEY, A ;

HILL, AP ;

HYDE, RM ;

LIVINGSTONE, DJ .

QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIPS, 1989, 8 (04) :288-296

[10] QUANTITATIVE STRUCTURE EXTRACTION RELATIONSHIPS - A MODEL FOR SUPERCRITICAL-FLUID EXTRACTION [J].

KANE, M ;

DEAN, JR ;

HITCHEN, SM ;

TOMLINSON, WR ;

TRANTER, RL ;

DOWLE, CJ .

ANALYST, 1993, 118 (10) :1261-1264