PROLACTIN SUPPRESSION OF LEUKOCYTE CHEMOTAXIS INVITRO

被引：16

作者：

HARRIS, RD ^{[1
]}

KAY, NE ^{[1
]}

SELJESKOG, EL ^{[1
]}

MURRAY, KJ ^{[1
]}

DOUGLAS, SD ^{[1
]}

机构：

[1] UNIV MINNESOTA,DEPT MED,IMMUNOL SECT,MINNEAPOLIS,MN 55455

来源：

JOURNAL OF NEUROSURGERY | 1979年 / 50卷 / 04期

关键词：

D O I：

10.3171/jns.1979.50.4.0462

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Leukocyte chemotaxis in vitro was studied for cells from patients with pituitary adenomas. Leukocytes obtained preoperatively from two of three patients with elevated serum prolactin levels demonstrated chemotaxic alterations described in other malignant disease. Statistically significant suppression of chemotaxis occurred in the leukocytes of four of 12 specimens from normal donors at concentrations of 1000 ng/ml, and in four of eight specimens at 2000 ng/ml of prolactin in preincubation media. Thus prolactin concentration may influence the motility of leukocytes. The variable neoplastic behavior of morphologically similar pituitary adenomas may, in part, reflect a neurohormonally altered host response to the presence of these lesions.

引用

页码：462 / 465

页数：4