SIMULTANEOUS ANALYSIS OF PHENYLGLYCOLS AND PHENYLETHANOLS IN HUMAN-URINE BY GAS CHROMATOGRAPHY-MASS SPECTROMETRY

被引：12

作者：

EDWARDS, DJ

RIZK, M

NEIL, J

机构：

[1] Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh

来源：

JOURNAL OF CHROMATOGRAPHY | 1979年 / 164卷 / 04期

关键词：

D O I：

10.1016/S0378-4347(00)81544-3

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A method is described for the determination of the neutral metabolites formed from catecholamines and various other structurally related phenylethylamines by using gas chromatography-chemical ionization-mass spectrometry. These metabolites (phenylglycols and phenylethanols) were extracted from urine specimens and converted to pentafluoropropionyl derivatives which were separated on either 3% OV-1, 3% SP-2250, or 3% QF-1 packed columns. Our results demonstrate the presence in human urine of p-hydroxyphenylglycol, a metabolite of octopamine. One patient excreted 13 and 91 μg/day of free and total (free + conjugated) p-hydroxyphenylglycol, respectively. Treatment with a monoamine oxidase inhibitor reduced the excretion of total p-hydroxyphenylglycol to 30% of baseline level. © 1979.

引用

页码：407 / 416

页数：10

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