DETERMINATION OF THE SURFACE-PROPERTIES OF 2 BATCHES OF SALBUTAMOL SULFATE BY INVERSE GAS-CHROMATOGRAPHY

被引：90

作者：

TICEHURST, MD

ROWE, RC

YORK, P

机构：

[1] UNIV BRADFORD,BRADFORD BD7 1DP,W YORKSHIRE,ENGLAND

[2] ZENECA PHARMACEUT,MACCLESFIELD SK10 2TG,CHESHIRE,ENGLAND

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 1994年 / 111卷 / 03期

基金：

英国工程与自然科学研究理事会;

关键词：

SALBUTAMOL SULFATE; INVERSE GAS CHROMATOGRAPHY; SURFACE PROPERTIES; BATCH TO BATCH VARIATION; SURFACE FREE ENERGY; ACID-BASE INTERACTIONS;

D O I：

10.1016/0378-5173(94)90347-6

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The surface properties of two batches of salbutamol sulphate, demonstrated to be chemically and structurally equivalent by FT-Raman spectroscopy and X-ray powder diffraction, were measured using a gas-solid chromatography technique, inverse gas chromatography (IGC). IGC was undertaken using polar and non-polar adsorbates (probes) at infinite dilution with salbutamol sulphate as the solid stationary phase. The retention behaviour of the probes was found to differ markedly between the two batches, implicating a-profound difference in surface energetics. This was reflected in the differences in calculated dispersive component of surface free energy (gamma(S)(D)) acid-base parameters.

引用

页码：241 / 249

页数：9

共 20 条

[1] ON THE CORRELATION BETWEEN THE RETENTION VOLUME OF SELECTED COMPOUNDS AND THE SURFACE FREE-ENERGY OF CONTROLLED POROSITY GLASSES [J].