ADSORPTION OF WATER ON CYCLOSPORINE-A, FROM ZERO TO FINITE SURFACE COVERAGE

被引:11
作者
DJORDJEVIC, NM
ROHR, G
HINTERLEITNER, M
SCHREIBER, B
机构
关键词
CYCLOSPORINE-A; WATER; INVERSE GC; ADSORPTION; BET ISOTHERM; ZERO SURFACE COVERAGE;
D O I
10.1016/0378-5173(92)90039-5
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
A gas-chromatographic technique was used to measure the adsorption of water at zero and finite surface coverage of the orthorhombic form of cyclosporin A. For calculation of the surface area, the BET adsorption isotherms of water at 373 K and nitrogen at 77 K were utilized. When nitrogen was used as adsorbate a lower value for the specific surface area was obtained. This could be explained in terms of the size and shape of the adsorbate molecule and its ability to access the internal surface of the adsorbent. Results obtained with the scanning electron microscope revealed small apertures on the adsorbent surface.
引用
收藏
页码:21 / 29
页数:9
相关论文
共 22 条
[1]   THE MOLECULAR-BASIS OF MOISTURE EFFECTS ON THE PHYSICAL AND CHEMICAL-STABILITY OF DRUGS IN THE SOLID-STATE [J].
AHLNECK, C ;
ZOGRAFI, G .
INTERNATIONAL JOURNAL OF PHARMACEUTICS, 1990, 62 (2-3) :87-95
[2]   The swelling of charcoal Part V. The saturation and immersion expansions and the heat of wetting [J].
Bangham, DH ;
Razouk, RI .
PROCEEDINGS OF THE ROYAL SOCIETY OF LONDON SERIES A-MATHEMATICAL AND PHYSICAL SCIENCES, 1938, 166 (A927) :0572-0586
[3]   The Gibbs adsorption equation and adsorption on solids. [J].
Bangham, DH .
TRANSACTIONS OF THE FARADAY SOCIETY, 1937, 33 (01) :0805-0810
[4]   The wetting of charcoal and the nature of the adsorbed phase formed from saturated vapours. [J].
Bangham, DH ;
Razouk, RI .
TRANSACTIONS OF THE FARADAY SOCIETY, 1937, 33 (02) :1463-1471
[5]   Adsorption of gases in multimolecular layers [J].
Brunauer, S ;
Emmett, PH ;
Teller, E .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1938, 60 :309-319
[6]   THE STOICHIOMETRY OF THE HYDRATION OF BETA-DICALCIUM SILICATE AND TRICALCIUM SILICATE AT ROOM TEMPERATURE [J].
BRUNAUER, S ;
KANTRO, DL ;
COPELAND, LE .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1958, 80 (04) :761-767
[7]  
BRUNAUER S, 1945, ADSORPTION GASES VAP, V1
[8]   A MICROCALORIMETRIC STUDY OF POWDER SURFACE ENERGETICS [J].
BUCKTON, G ;
BEEZER, AE .
INTERNATIONAL JOURNAL OF PHARMACEUTICS, 1988, 41 (1-2) :139-145
[9]  
Conder J. R., 1979, PHYSICOCHEMICAL MEAS
[10]  
De Boer J.H., 1953, DYNAMICAL CHARACTER, P54