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THE SPECIFICITY OF INHIBITION OF DEBRISOQUINE 4-HYDROXYLASE ACTIVITY BY QUINIDINE AND QUININE IN THE RAT IS THE INVERSE OF THAT IN MAN

被引：149
作者：
KOBAYASHI, S [1 ]
MURRAY, S [1 ]
WATSON, D [1 ]
SESARDIC, D [1 ]
DAVIES, DS [1 ]
BOOBIS, AR [1 ]
机构：
[1] ROYAL POSTGRAD MED SCH,DEPT CLIN PHARMACOL,DU CANE RD,LONDON W12 0NN,ENGLAND
来源：
BIOCHEMICAL PHARMACOLOGY | 1989年 / 38卷 / 17期
基金：
英国惠康基金;
关键词：
D O I：
10.1016/0006-2952(89)90433-4
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
引用
收藏
页码：2795 / 2799
页数：5
相关论文
共 21 条
  • [1] ANIMAL MODELING OF HUMAN POLYMORPHIC DRUG OXIDATION - THE METABOLISM OF DEBRISOQUINE AND PHENACETIN IN RAT INBRED STRAINS
    ALDABBAGH, SG
    IDLE, JR
    SMITH, RL
    [J]. JOURNAL OF PHARMACY AND PHARMACOLOGY, 1981, 33 (03) : 161 - 164
  • [2] INVITRO STUDIES OF INDUCTION AND INHIBITION OF DRUG OXIDATION IN MAN
    BOOBIS, AR
    MURRAY, S
    SEDDON, CE
    DAVIES, DS
    [J]. PHARMACOLOGY & THERAPEUTICS, 1987, 33 (01) : 101 - 108
  • [3] BUFURALOL 1'-HYDROXYLASE ACTIVITY OF THE RAT - STRAIN DIFFERENCES AND THE EFFECTS OF INHIBITORS
    BOOBIS, AR
    SEDDON, CE
    DAVIES, DS
    [J]. BIOCHEMICAL PHARMACOLOGY, 1986, 35 (17) : 2961 - 2965
  • [4] MONO-OXYGENASE ACTIVITY OF HUMAN-LIVER IN MICROSOMAL FRACTIONS OF NEEDLE-BIOPSY SPECIMENS
    BOOBIS, AR
    BRODIE, MJ
    KAHN, GC
    FLETCHER, DR
    SAUNDERS, JH
    DAVIES, DS
    [J]. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 1980, 9 (01) : 11 - 19
  • [5] BOOBIS AR, 1983, MOL PHARMACOL, V23, P474
  • [6] ATTEMPTS TO PHENOTYPE HUMAN-LIVER SAMPLES INVITRO FOR DEBRISOQUINE 4-HYDROXYLASE ACTIVITY
    BOOBIS, AR
    HAMPDEN, CE
    MURRAY, S
    BEAUNE, P
    DAVIES, DS
    [J]. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 1985, 19 (06) : 721 - 729
  • [7] BIPHASIC O-DEETHYLATION OF PHENACETIN AND 7-ETHOXYCOUMARIN BY HUMAN AND RAT-LIVER MICROSOMAL FRACTIONS
    BOOBIS, AR
    KAHN, GC
    WHYTE, C
    BRODIE, MJ
    DAVIES, DS
    [J]. BIOCHEMICAL PHARMACOLOGY, 1981, 30 (17) : 2451 - 2456
  • [8] CHARACTERIZATION OF A HUMAN-LIVER CYTOCHROME-P-450 INVOLVED IN THE OXIDATION OF DEBRISOQUINE AND OTHER DRUGS BY USING ANTIBODIES RAISED TO THE ANALOGOUS RAT ENZYME
    DISTLERATH, LM
    GUENGERICH, FP
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1984, 81 (23): : 7348 - 7352
  • [9] DEBRISOQUINE 4-HYDROXYLASE - CHARACTERIZATION OF A NEW P450 GENE SUBFAMILY, REGULATION, CHROMOSOMAL MAPPING, AND MOLECULAR ANALYSIS OF THE DA RAT POLYMORPHISM
    GONZALEZ, FJ
    MATSUNAGA, T
    NAGATA, K
    MEYER, UA
    NEBERT, DW
    PASTEWKA, J
    KOZAK, CA
    GILLETTE, J
    GELBOIN, HV
    HARDWICK, JP
    [J]. DNA-A JOURNAL OF MOLECULAR & CELLULAR BIOLOGY, 1987, 6 (02): : 149 - 161
  • [10] CHARACTERIZATION OF THE COMMON GENETIC-DEFECT IN HUMANS DEFICIENT IN DEBRISOQUINE METABOLISM
    GONZALEZ, FJ
    SKODA, RC
    KIMURA, S
    UMENO, M
    ZANGER, UM
    NEBERT, DW
    GELBOIN, HV
    HARDWICK, JP
    MEYER, UA
    [J]. NATURE, 1988, 331 (6155) : 442 - 446
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