ANTITUMOR-ACTIVITY OF MARINE-ALGAE

被引:92
作者
NODA, H [1 ]
AMANO, H [1 ]
ARASHIMA, K [1 ]
NISIZAWA, K [1 ]
机构
[1] NIHON UNIV, COLL AGR & VET MED, DEPT FISHERIES, SETAGAYA KU, TOKYO 154, JAPAN
关键词
antitumor; Ehrlich carcinoma; lipids; Meth-A fibrosarcoma; polysaccharides; seaweed;
D O I
10.1007/BF00040290
中图分类号
Q17 [水生生物学];
学科分类号
071004 ;
摘要
Powdered tissue from 46 species of air-dried marine algae (four green, 21 brown and 21 red algae) were screened for antitumor activity. Significant activity against Ehrlich carcinoma was found in the brown algae Scytosiphon lomentaria (69.8% inhibition), Lessonia nigrescens (60.0%), Laminaria japonica (57.6%), Sargassum ringgoldianum (46.5%), the red algae Porphyra yezoensis (53.2%) and Eucheuma gelatinae (52.1%) and the green alga Enteromorpha prolifera (51.7%). Five brown and four red algae showed appreciable antitumor activity against Meth-A fibrosarcoma. To identify specific molecules with antitumor activity, 15 kinds of polysaccharide preparations of seaweed origin and 24 kinds of lipid fractions extracted from various seaweeds were tested. Appreciable inhibition of Ehrlich carcinoma was found for fucoidan preparations from Undaria pinnatifida and Sargassum ringgoldianum, for carrageenans and for porphyran. Several glycolipid and phospholipid fractions from brown and red algae were effective against Meth-A fibrosarcoma. © 1990 Kluwer Academic Publishers.
引用
收藏
页码:577 / 584
页数:8
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