ISOLATION OF FATTY ACIDS WITH ANTITUMOR ACTIVITY FROM FUNGAL MYCELIA - STUDIES ON ANTIVIRAL AND ANTITUMOR ANTIBIOTICS .7.

被引：20

作者：

ANDO, K

SUZUKI, S

SUZUKI, K

KODAMA, K

KATO, A

TAMURA, G

ARIMA, K

机构：

[1] Laboratory of Microbiology, Department of Agricultural Chemistry, University of Tokyo

[2] Research Laboratories, Chugai Pharmaceutical Co., Ltd., Tokyo

来源：

JOURNAL OF ANTIBIOTICS | 1969年 / 22卷 / 01期

关键词：

D O I：

10.7164/antibiotics.22.18

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

In our screening for antitumor antibiotics using the Ehrlich ascites tumor, acetone extracts of the mycelia of Penicillium crustosum, Penicillium tardum, Cephalosporium diospyri and Sepedonium ampullosporum showed significant antitumor activity. These fungi were selected because of cytotoxicity or antiviral activity on chick embryo fibroblast cell monolayers. The extracts were fractionated by silica gel column chromatography and the active principles were obtained as colorless oils which showed the characteristic infrared absorption bands of long-chain fatty acids. The active principles exert marked antitumor activity against EHRLICH ascites tumor, although they showed neither antiviral activity nor inhibitory activity against microorganisms. © 1969, JAPAN ANTIBIOTICS RESEARCH ASSOCIATION. All rights reserved.

引用

页码：18 / &

共 5 条

[1] CHEMICAL STUDY OF FATTY ACIDS WITH ANTITUMOR ACTIVITY ISOLATED FROM FUNGAL MYCELIA - STUDIES ON ANTIVIRAL AND ANTITUMOR ANTIBIOTICS .8. [J].