TRANSMISSION BLOCKING ANTIBODY OF THE PLASMODIUM-FALCIPARUM ZYGOTE OOKINETE SURFACE PROTEIN PFS25 ALSO INFLUENCES SPOROZOITE DEVELOPMENT

被引：31

作者：

LENSEN, AHW ^{[1
]}

VANGEMERT, GJA ^{[1
]}

BOLMER, MG ^{[1
]}

MEIS, JFGM ^{[1
]}

KASLOW, D ^{[1
]}

MEUWISSEN, JHET ^{[1
]}

PONNUDURAI, T ^{[1
]}

机构：

[1] NIAID,PARASIT DIS LAB,BETHESDA,MD 20892

来源：

PARASITE IMMUNOLOGY | 1992年 / 14卷 / 05期

关键词：

MALARIA; PLASMODIUM-FALCIPARUM; TRANSMISSION BLOCKADE; SPOROZOITES;

D O I：

10.1111/j.1365-3024.1992.tb00021.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The Plasmodium falciparum zygote/ookinete surface protein, Pfs25, persists in the oocyst wall throughout its development. Anti-25 kD transmission blocking antibody, given to infected Anopheles stephensi or A. gambiae mosquitoes in an additional bloodmeal, 3-6 days after being fed gametocyte infected blood, penetrated the oocyst and reacted with the 25 kD protein within it. This reaction caused a significant reduction in the number of developing sporozoites. Mouse serum containing antibodies raised by immunization with a recombinant 25 kD yeast product showed a similar effect.

引用

收藏

页码：471 / 479

页数：9

相关论文

共 15 条

[1] RECOMBINANT PFS25 PROTEIN OF PLASMODIUM-FALCIPARUM ELICITS MALARIA TRANSMISSION-BLOCKING IMMUNITY IN EXPERIMENTAL-ANIMALS [J].

BARR, PJ ;

GREEN, KM ;

GIBSON, HL ;

BATHURST, IC ;

QUAKYI, IA ;

KASLOW, DC .

JOURNAL OF EXPERIMENTAL MEDICINE, 1991, 174 (05) :1203-1208

[2] UPTAKE OF H-3 ADENOSINE AND H-3-THYMIDINE BY OOCYSTS OF P-BERGHEI-BERGHEI [J].

DAVIES, EE ;

HOWELLS, RE .

TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE, 1973, 67 (01) :20-20

[3] INDUCTION OF PLASMODIUM-FALCIPARUM TRANSMISSION-BLOCKING ANTIBODIES BY RECOMBINANT VACCINIA VIRUS [J].

KASLOW, DC ;

ISAACS, SN ;

QUAKYI, IA ;

GWADZ, RW ;

MOSS, B ;

KEISTER, DB .

SCIENCE, 1991, 252 (5010) :1310-1313

[4] PLASMODIUM-FALCIPARUM OOKINETES MIGRATE INTERCELLULARLY THROUGH ANOPHELES-STEPHENSI MIDGUT EPITHELIUM [J].

MEIS, JFGM ;

POOL, G ;

VANGEMERT, GJ ;

LENSEN, AHW ;

PONNUDURAI, T ;

MEUWISSEN, JHET .

PARASITOLOGY RESEARCH, 1989, 76 (01) :13-19

[5] THE MALARIAL INFECTIVITY OF AN AFRICAN VILLAGE POPULATION TO MOSQUITOES (ANOPHELES-GAMBIAE) - A RANDOM XENODIAGNOSTIC SURVEY [J].

MUIRHEADTHOMSON, RC .

AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 1957, 6 (06) :971-979

[6] DIFFERENTIAL INFECTIVITY OF PLASMODIUM FOR MOSQUITOS [J].

PONNUDURAI, T ;

BILLINGSLEY, PF ;

RUDIN, W .

PARASITOLOGY TODAY, 1988, 4 (11) :319-321

[7] FEEDING-BEHAVIOR AND SPOROZOITE EJECTION BY INFECTED ANOPHELES-STEPHENSI [J].

PONNUDURAI, T ;

LENSEN, AHW ;

VANGEMERT, GJA ;

BOLMER, MG ;

MEUWISSEN, JHET .

TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE, 1991, 85 (02) :175-180

[8] INFECTIVITY OF CULTURED PLASMODIUM-FALCIPARUM GAMETOCYTES TO MOSQUITOS [J].

PONNUDURAI, T ;

LENSEN, AHW ;

VANGEMERT, GJA ;

BENSINK, MPE ;

BOLMER, M ;

MEUWISSEN, JHET .

PARASITOLOGY, 1989, 98 :165-173

[9]

POSTHUMA G, 1988, EUR J CELL BIOL, V46, P18

[10] A QUANTITATIVE STUDY OF NATURALLY-ACQUIRED MALARIA INFECTIONS IN ANOPHELES GAMBIAE AND ANOPHELES FUNESTUS IN A HIGHLY MALARIOUS AREA OF EAST AFRICA [J].

PRINGLE, G .

TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE, 1966, 60 (05) :626-+