A POSSIBLE ROLE FOR PHOSPHOLIPASES IN THE RELEASE OF NEUROTRANSMITTER AMINO-ACIDS FROM ISCHEMIC RAT CEREBRAL-CORTEX

被引：76

作者：

OREGAN, MH ^{[1
]}

SMITHBARBOUR, M ^{[1
]}

PERKINS, LM ^{[1
]}

PHILLIS, JW ^{[1
]}

机构：

[1] WAYNE STATE UNIV,SCH MED,DEPT PHYSIOL,DETROIT,MI 48201

来源：

NEUROSCIENCE LETTERS | 1995年 / 185卷 / 03期

关键词：

MEPACRINE; PHOSPHOLIPASE A(2); PHOSPHOLIPASE C; ASPARTATE; GLUTAMATE;

D O I：

10.1016/0304-3940(95)11259-Y

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The involvement of phospholipases in ischemia-evoked release of aspartate, glutamate, glycine, and GABA from the cerebral cortex was studied in a four vessel occlusion rat model of cerebral ischemia/reperfusion. In comparison with the control group, the phospholipase A(2) inhibitor mepacrine significantly decreased the ischemia-evoked efflux of transmitter amino acids into cortical superfusates. Direct application of phospholipases A(2) or C to the cerebral cortex of non-ischemic animals resulted in a significant increase in amino acid levels. These results suggest that neurotransmitter release following cerebral ischemia may involve phospholipase induced plasma membrane disruption.

引用

页码：191 / 194

页数：4

共 17 条

[11]

Perry TL, 1982, HDB NEUROCHEMISTRY, P151

[12] CHARACTERIZATION OF GLUTAMATE, ASPARTATE, AND GABA RELEASE FROM ISCHEMIC RAT CEREBRAL-CORTEX [J].

PHILLIS, JW ;

SMITHBARBOUR, M ;

PERKINS, LM ;

OREGAN, MH .

BRAIN RESEARCH BULLETIN, 1994, 34 (05) :457-466

[13] INDOMETHACIN MODULATES ISCHEMIA-EVOKED RELEASE OF GLUTAMATE AND ADENOSINE FROM THE RAT CEREBRAL-CORTEX [J].

PHILLIS, JW ;

SMITHBARBOUR, M ;

PERKINS, LM ;

OREGAN, MH .

BRAIN RESEARCH, 1994, 652 (02) :353-356

[14] ROLE OF PHOSPHOLIPASES-A2 AND PHOSPHOLIPASE-C IN MYOCARDIAL ISCHEMIC REPERFUSION INJURY [J].

PRASAD, MR ;

POPESCU, LM ;

MORARU, II ;

LIU, X ;

MAITY, S ;

ENGELMAN, RM ;

DAS, DK .

AMERICAN JOURNAL OF PHYSIOLOGY, 1991, 260 (03) :H877-H883

[15] SWELLING, ACIDOSIS, AND IRREVERSIBLE DAMAGE OF GLIAL-CELLS FROM EXPOSURE TO ARACHIDONIC-ACID IN-VITRO [J].

STAUB, F ;

WINKLER, A ;

PETERS, J ;

KEMPSKI, O ;

KACHEL, V ;

BAETHMANN, A .

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 1994, 14 (06) :1030-1039

[16] ACTION OF PHOSPHOLIPASE-A2 AND PHOSPHOLIPASE-C ON FREE FATTY-ACID RELEASE DURING COMPLETE ISCHEMIA IN RAT NEOCORTEX - EFFECT OF PHOSPHOLIPASE-C INHIBITOR AND N-METHYL-D-ASPARTATE ANTAGONIST [J].

UMEMURA, A ;

MABE, H ;

NAGAI, H ;

SUGINO, F .

JOURNAL OF NEUROSURGERY, 1992, 76 (04) :648-651

[17]

VANDERVUSSE GJ, 1994, ANN NY ACAD SCI, V723, P1

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