CARBON-11-METHIONINE AND PET IN EVALUATION OF TREATMENT RESPONSE OF BREAST-CANCER

被引:62
作者
HUOVINEN, R
LESKINENKALLIO, S
NAGREN, K
LEHIKOINEN, P
RUOTSALAINEN, U
TERAS, M
机构
[1] UNIV TURKU, CENT HOSP, DEPT NUCL MED, TURKU MED CYCLOTRON PET CTR, SF-20520 TURKU 52, FINLAND
[2] UNIV TURKU, RADIOCHEM LAB, SF-20500 TURKU 50, FINLAND
关键词
D O I
10.1038/bjc.1993.143
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Uptake of L-methyl-C-11-methionine (C-11-methionine) in breast cancer metastases was studied with positron emission tomography (PET). Eight patients with soft tissue metastases were studied twice: before the onset of chemotherapy (4), hormonal therapy (3) or radiotherapy (1) and 3-14 weeks later. The radioactivity concentration of the low molecular weight fraction of venous plasma samples separated by fast gel filtration was used as input function. The input corrected uptake rate of C-11-methionine (K(i)) in breast cancer metastases before the treatment ranged between 0.035 and 0.186 1 min-1 and the standardised uptake value (SUV) between 2.0 and 11.4. The uptake of C-11-methionine into the metastases decreased when clinical objective stability or regression of the metastases was later obtained and increased in cases where progressive disease was seen during treatment. We conclude that metabolic changes in the amino acid metabolism detected by PET precede the clinical response, and may be of clinical value in predicting the treatment response.
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页码:787 / 791
页数:5
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