INTERMEDIATE FILAMENTS IN THE HUMAN PITUITARY-GLAND - AN IMMUNOHISTOCHEMICAL STUDY

被引:24
作者
HALLIDAY, WC
ASA, SL
KOVACS, K
SCHEITHAUER, BW
机构
[1] UNIV MANITOBA, DEPT PATHOL, WINNIPEG R3T 2N2, MANITOBA, CANADA
[2] ST MICHAELS HOSP, DEPT PATHOL, TORONTO M5B 1W8, ONTARIO, CANADA
[3] MAYO CLIN & MAYO FDN, DEPT PATHOL, ROCHESTER, MN 55905 USA
关键词
D O I
10.1017/S0317167100030328
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Normal pituitaries, pituitaries showing CHC and selected adenomas were assessed for their possible content of intermediate filaments (IF), using immunohistochemical techniques. Normal pituitaries were stained for each of the five known IF (Cytokeratins (CK), glial fibrillary acidic protein (GFAP), desmin, vimentin, and neurofilaments (NF)). Desmin could not be demonstrated, and NF staining was limited to processes in the posterior gland. In serial sections, CK was demonstrated in some corticotrophs, somatotrophs, and lactotrophs. Vimentin was limited to processes in the posterior gland. Folliculo-stellate cells (FSC), demonstrated by staining for SlOO protein, exhibited a small subpopulation staining for CK, and another subpopulation staining for GFAP. GFAP was also demonstrated in glial processes in the posterior gland. Cells showing Crooke's hyaline change stained intensely for CK. Null cell adenomas did not stain for CK. Corticotroph adenomas, somatotroph adenomas, with or without fibrous bodies, and lactotroph adenomas contain CK-immunoreactive cells. We conclude that CK is the major IF present in the anterior pituitary gland, within some normal corticotrophs, somatotrophs and lactotrophs, and also in adenomas derived from these cells. © 1990, Canadian Neurological Sciences Federation. All rights reserved.
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页码:131 / 136
页数:6
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