SYNERGISTIC ENHANCEMENT OF THYROID-TUMOR INDUCTION BY 2,4-DIAMINOANISOLE SULFATE, N,N'-DIETHYLTHIOUREA AND 4,4'-THIODIANILINE IN MALE F344 RATS

被引：8

作者：

HASEGAWA, R ^{[1
]}

SHIRAI, T ^{[1
]}

HAKOI, K ^{[1
]}

WADA, S ^{[1
]}

YAMAGUCHI, K ^{[1
]}

TAKAYAMA, S ^{[1
]}

机构：

[1] NATL CANC CTR,RES INST,DIV GROWTH FACTOR,TOKYO 104,JAPAN

来源：

CARCINOGENESIS | 1991年 / 12卷 / 08期

关键词：

D O I：

10.1093/carcin/12.8.1515

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Three thyroid carcinogens, 2,4-diaminoanisole sulfate (DAAS), NN'-diethylthiourea (DETU) and 4,4'-thiodianiline (TDA), were simultaneously administered in the diet to male F344 rats at one-third the concentration of the reported TD50 levels (610, 200 and 46 p.p.m. respectively) for 52 weeks. The resultant incidence of thyroid adenocarcinomas in the combined treatment group (18/18: 100%) was significantly higher than those in each individual treatment group (DAAS, 0/21; DETU, 1/21; TDA, 2/20). Hepatocellular carcinomas (9/18, 50%) and lung adenomas (6/18, 33%) were also induced by the combined treatment, the incidences being higher than in the TDA group (3/20, 15% and 4/20, 20% respectively) to which these tumors- were limited in the three groups treated with single chemicals. Thus, the results indicated that the three carcinogens exert apparent synergism in thyroid carcinogenesis when administered simultaneously.

引用

页码：1515 / 1518

页数：4

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