PROTEIN-BINDING OF 4 ANTIEPILEPTIC DRUGS IN MATERNAL AND UMBILICAL-CORD SERUM

被引：20

作者：

TAKEDA, A ^{[1
]}

OKADA, H ^{[1
]}

TANAKA, H ^{[1
]}

IZUMI, M ^{[1
]}

ISHIKAWA, S ^{[1
]}

NORO, T ^{[1
]}

机构：

[1] NAGOYA NATL HOSP,DEPT PHARM,NAGOYA 460,JAPAN

来源：

EPILEPSY RESEARCH | 1992年 / 13卷 / 02期

关键词：

FETAL DRUG LEVEL; PROTEIN BINDING; VALPROIC ACID; PHENOBARBITAL; PHENYTOIN; CARBAMAZEPINE;

D O I：

10.1016/0920-1211(92)90070-A

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The total and protein free levels of 4 antiepileptic drugs (AEDs) in serum from 35 maternity patients who had been treated with AED monotherapy throughout pregnancy were studied. Results were compared with those in the umbilical cord serum at the time of delivery, and the placental transfer of AEDs was evaluated from the viewpoint of the protein binding capacity of the drug. The materials consisted of 35 samples of maternal and umbilical cord serum in total and included 13 patients on phenobarbital (PB), 7 on phenytoin (PHT), 7 on carbamazepine (CBZ) and 8 on valproic acid (VPA). The mean fetal/maternal total concentration ratios were 0.86, 0.91, 0.73 and 1.59 for PB, PHT, CBZ and VPA, respectively, only the VPA ratio being above 1. On the other hand, the mean fetal/maternal free fraction ratios were 1.13, 1.10, 1.42 and 0.50 for PB, PHT, CBZ and VPA, respectively, only the VPA ratio being less than 1. Correlation of the 2 ratios showed a reciprocal proportion with a correlation coefficient of -0.90 (P <0.005). It was considered that the fetal/maternal total concentration ratio of 4 AEDs was regulated by the fetal/maternal free fraction ratio of the corresponding AEDs and that the difference in fetal/maternal free fraction ratio depended on the type of drug being administered.

引用

页码：147 / 151

页数：5

共 20 条

[1] FREE FRACTION OF VALPROIC ACID - INVITRO TIME-DEPENDENT INCREASE AND CORRELATION WITH FREE FATTY-ACID CONCENTRATION IN HUMAN-PLASMA AND SERUM [J].