RECOMBINANT CDNA ENCAPSULATION IN SMALL LIPOSOMES WITH HEPATOCYTE ACCESS ABILITY

被引：9

作者：

ALINO, SF

BOBADILLA, M

UNDA, FJ

GARCIASANZ, M

HILARIO, E

LEJARRETA, M

机构：

[1] Department of Pharmacology, Faculty of Medicine and Density, University of Valencia, 46010, Valencia

[2] Department of Cell Biology and Morphological Sciences, Faculty of Medicine and Dentistry, University of the Basque Country, Leioa, 48940, Vizcaya

来源：

JOURNAL OF MICROENCAPSULATION | 1993年 / 10卷 / 02期

关键词：

D O I：

10.3109/02652049309104382

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Liposomal encapsulation efficiency of a recombinant cDNA was studied by several procedures. We observed that supernatant fraction of ultracentrifuged liposomes prepared by extrusion through polycarbonate filters of 400 nm pore size yielded a very homogeneous suspension of small (50 nm diameter) unilamellar liposomes with highest DNA/lipid ratio and great ability to access to hepatocytes.

引用

页码：163 / 170

页数：8