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INFLUENCE OF 12-WEEK NICOTINE TREATMENT AND DIETARY COPPER AN BLOOD-PRESSURE AND INDEXES OF THE ANTIOXIDANT SYSTEM IN MALE SPONTANEOUS HYPERTENSIVE RATS

被引：7
作者：
BUI, LM
KEEN, CL
DUBICK, MA
机构：
[1] UNIV CALIF DAVIS,DEPT NUTR,DAVIS,CA 95616
[2] UNIV CALIF DAVIS,DEPT INTERNAL MED,DAVIS,CA 95616
[3] LETTERMAN ARMY INST RES,DIV MIL TRAUMA RES,SAN FRANCISCO,CA 94129
[4] USA,INST SURG RES,FT SAM HOUSTON,TX 78234
来源：
BIOLOGICAL TRACE ELEMENT RESEARCH | 1994年 / 46卷 / 1-2期
关键词：
SHR; TRACE ELEMENTS; ANTIOXIDANT ENZYMES; NICOTINE; HYPERTENSION; DRUG-NUTRIENT; ZINC; COPPER; IRON; MANGANESE;
D O I：
10.1007/BF02790068
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Nicotine treatment and copper (Cu) deficiency have been associated with an increased production of reactive oxygen species that may contribute to the development and/or progression of cardiovascular diseases (CVD). The present study investigated the influence of dietary Cu intake on the response to chronic nicotine treatment in spontaneous hypertensive rats (SHR) with respect to tissue trace mineral levels, several components of the oxidant defense system, and Lipid peroxidation rates. SHR weighing 100-110 g were fed a Cu deficient diet (-Cu) (0.5 mu g Cu/g) for 14 d prior to nicotine treatment.
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收藏
页码：67 / 78
页数：12
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