Catalytic asymmetric iodocarbocyclization reaction

被引：40

作者：

Inoue, T

Kitagawa, O

Ochiai, O

Shiro, M

Taguchi, T

机构：

[1] TOKYO COLL PHARM,HACHIOJI,TOKYO 19203,JAPAN

[2] RIGAKU CORP,AKISHIMA,TOKYO 196,JAPAN

来源：

TETRAHEDRON LETTERS | 1995年 / 36卷 / 51期

关键词：

D O I：

10.1016/0040-4039(95)02021-G

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The iodocarbocyclization reactions of 4-pentenylmalonate derivatives using 20 mol% of the chiral titamium complex in the presence of 12 and 2,6-dimethoxypyridine proceeded with high enantioselectivity to give good yields of cyclopentane cyclopentone derivatives. The origin of enantioselectivity in the present reaction is discussed on the basis of X-ray crystal structural data of the chiral titanium complex from acetylacetone, chiral diol and Ti(IV).

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页码：9333 / 9336

页数：4

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