SEPARATION OF DIASTEREOMERS USING A LOW-COST PREPARATIVE MEDIUM-PRESSURE LIQUID CHROMATOGRAPH

被引：130

作者：

MEYERS, AI ^{[1
]}

SLADE, J ^{[1
]}

SMITH, RK ^{[1
]}

MIHELICH, ED ^{[1
]}

HERSHENSON, FM ^{[1
]}

LIANG, CD ^{[1
]}

机构：

[1] SEARLE LABS,DEPT CHEM RES,CHICAGO,IL 60680

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1979年 / 44卷 / 13期

关键词：

D O I：

10.1021/jo01327a045

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A series of diastereomeric oxazolines (2 and 5) derived from asymmetric addition of organometallics to the prochiral oxazolines 1 and 4 have been examined on an efficient preparative liquid chromatograph. The pure diastereomers were readily obtained using this component system, and enantiomerically pure acids 3 and 6 were isolated. It is suggested that [γ]D values for pure chiral products be recorded only after this separation scheme is employed. Details for the construction of the liquid chromatograph and its operation are given. © 1979, American Chemical Society. All rights reserved.

引用

页码：2247 / 2249

页数：3

共 11 条

[1] NUCLEAR MAGNETIC-RESONANCE ENANTIOMER REAGENTS - CONFIGURATIONAL CORRELATIONS VIA NUCLEAR MAGNETIC-RESONANCE CHEMICAL-SHIFTS OF DIASTEREOMERIC MANDELATE, O-METHYLMANDELATE, AND ALPHA-METHOXY-ALPHA-TRIFLUOROMETHYLPHENYLACETATE (MTPA) ESTERS [J].