FREQUENCY OF ADMINISTRATION OF GROWTH-HORMONE - AN IMPORTANT FACTOR IN DETERMINING GROWTH-RESPONSE TO EXOGENOUS GROWTH-HORMONE

被引：30

作者：

HINDMARSH, PC

STANHOPE, R

PREECE, MA

BROOK, CGD

机构：

[1] MIDDLESEX HOSP,ENDOCRINE UNIT,MORTIMER ST,LONDON W1N 8AA,ENGLAND

[2] INST CHILD HLTH,LONDON WC1N 1EH,ENGLAND

来源：

HORMONE RESEARCH | 1990年 / 33卷

关键词：

Growth hormone pulsatility; Growth hormone therapy; Prediction of response to growth hormone;

D O I：

10.1159/000181590

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Growth hormone (GH) secretion in man occurs in a pulsatile manner with a dominant periodicity of 200 min. Animal studies and growth hormone-releasing hormone therapeutic studies in man demonstrate the importance of the frequency of GH pulses on the growth response observed. Daily injections of GH produce effective growth. More frequent regimens may be beneficial to prevent waining of the growth spurt induced by GH therapy. © 1990 S. Karger AG, Basel.

引用

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页码：83 / 89

页数：7

相关论文

共 36 条

[1] PHYSIOLOGICAL GROWTH-HORMONE SECRETION IN CHILDREN WITH SHORT STATURE AND INTRA-UTERINE GROWTH-RETARDATION [J].

ACKLAND, FM ;

STANHOPE, R ;

EYRE, C ;

HAMILL, G ;

JONES, J ;

PREECE, MA .

HORMONE RESEARCH, 1988, 30 (06) :241-245

[2] ANALYSES OF 24-HOUR GROWTH-HORMONE PROFILES IN CHILDREN - RELATION TO GROWTH [J].

ALBERTSSONWIKLAND, K ;

ROSBERG, S .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1988, 67 (03) :493-500

[3] DAILY SUBCUTANEOUS ADMINISTRATION OF HUMAN GROWTH-HORMONE IN GROWTH-HORMONE DEFICIENT CHILDREN [J].

ALBERTSSONWIKLAND, K ;

WESTPHAL, O ;

WESTGREN, U .

ACTA PAEDIATRICA SCANDINAVICA, 1986, 75 (01) :89-97

[4] CONTINUOUS SUBCUTANEOUS GHRH(1-29)NH2 PROMOTES GROWTH OVER 1 YEAR IN SHORT, SLOWLY GROWING CHILDREN [J].

BRAIN, CE ;

HINDMARSH, PC ;

BROOK, CGD .

CLINICAL ENDOCRINOLOGY, 1990, 32 (02) :153-163

[5] GROWTH-HORMONE SECRETORY PROFILES IN CONSCIOUS FEMALE RATS [J].

CLARK, RG ;

CARLSSON, LMS ;

ROBINSON, ICAF .

JOURNAL OF ENDOCRINOLOGY, 1987, 114 (03) :399-407

[6] GROWTH-HORMONE RESPONSES TO MULTIPLE INJECTIONS OF A FRAGMENT OF HUMAN GROWTH HORMONE-RELEASING FACTOR IN CONSCIOUS MALE AND FEMALE RATS [J].

CLARK, RG ;

ROBINSON, ICAF .

JOURNAL OF ENDOCRINOLOGY, 1985, 106 (03) :281-289

[7] INTRAVENOUS GROWTH-HORMONE - GROWTH-RESPONSES TO PATTERNED INFUSIONS IN HYPOPHYSECTOMIZED RATS [J].

CLARK, RG ;

JANSSON, JO ;

ISAKSSON, O ;

ROBINSON, ICAF .

JOURNAL OF ENDOCRINOLOGY, 1985, 104 (01) :53-61

[8]

DARENDELILER F, 1990, IN PRESS J ENDOCR

[9] A DOSE-RESPONSE CURVE FOR HUMAN GROWTH-HORMONE [J].

FRASIER, SD ;

COSTIN, G ;

LIPPE, BM ;

ACETO, T ;

BUNGER, PF .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1981, 53 (06) :1213-1217

[10] THE RELATIONSHIP BETWEEN HEIGHT VELOCITY AND GROWTH-HORMONE SECRETION IN SHORT PREPUBERTAL CHILDREN [J].

HINDMARSH, P ;

SMITH, PJ ;

BROOK, CGD ;

MATTHEWS, DR .

CLINICAL ENDOCRINOLOGY, 1987, 27 (05) :581-591

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