FREQUENCY OF ADMINISTRATION OF GROWTH-HORMONE - AN IMPORTANT FACTOR IN DETERMINING GROWTH-RESPONSE TO EXOGENOUS GROWTH-HORMONE

被引：30

作者：

HINDMARSH, PC

STANHOPE, R

PREECE, MA

BROOK, CGD

机构：

[1] MIDDLESEX HOSP,ENDOCRINE UNIT,MORTIMER ST,LONDON W1N 8AA,ENGLAND

[2] INST CHILD HLTH,LONDON WC1N 1EH,ENGLAND

来源：

HORMONE RESEARCH | 1990年 / 33卷

关键词：

Growth hormone pulsatility; Growth hormone therapy; Prediction of response to growth hormone;

D O I：

10.1159/000181590

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Growth hormone (GH) secretion in man occurs in a pulsatile manner with a dominant periodicity of 200 min. Animal studies and growth hormone-releasing hormone therapeutic studies in man demonstrate the importance of the frequency of GH pulses on the growth response observed. Daily injections of GH produce effective growth. More frequent regimens may be beneficial to prevent waining of the growth spurt induced by GH therapy. © 1990 S. Karger AG, Basel.

引用

页码：83 / 89

页数：7

共 36 条

[31] THE MECHANISM OF THE ADOLESCENT GROWTH SPURT INDUCED BY LOW-DOSE PULSATILE GNRH TREATMENT [J].